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Research ArticleExperimental Studies

The PARP Inhibitor, ABT-888 Potentiates Temozolomide: Correlation with Drug Levels and Reduction in PARP Activity In Vivo

JOANN P. PALMA, LUIS E. RODRIGUEZ, VELITCHKA D. BONTCHEVA-DIAZ, JENNIFER J. BOUSKA, GAIL BUKOFZER, MILAGROS COLON-LOPEZ, RAN GUAN, KENNETH JARVIS, ERIC F. JOHNSON, VERED KLINGHOFER, XUESONG LIU, AMANDA OLSON, MARY J. SALTARELLI, YAN SHI, JASON A. STAVROPOULOS, GUI-DONG ZHU, THOMAS D. PENNING, YAN LUO, VINCENT L. GIRANDA, SAUL H. ROSENBERG, DAVID J. FROST and CHERRIE K. DONAWHO
Anticancer Research September 2008, 28 (5A) 2625-2635;
JOANN P. PALMA
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LUIS E. RODRIGUEZ
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VELITCHKA D. BONTCHEVA-DIAZ
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JENNIFER J. BOUSKA
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GAIL BUKOFZER
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MILAGROS COLON-LOPEZ
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RAN GUAN
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KENNETH JARVIS
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ERIC F. JOHNSON
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VERED KLINGHOFER
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XUESONG LIU
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AMANDA OLSON
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MARY J. SALTARELLI
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YAN SHI
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JASON A. STAVROPOULOS
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GUI-DONG ZHU
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THOMAS D. PENNING
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YAN LUO
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VINCENT L. GIRANDA
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SAUL H. ROSENBERG
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DAVID J. FROST
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CHERRIE K. DONAWHO
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  • For correspondence: cherrie.donawho{at}abbott.com
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Article Information

vol. 28 no. 5A 2625-2635
PMID 
19035287

Published By 
International Institute of Anticancer Research
Print ISSN 
0250-7005
Online ISSN 
1791-7530
History 
  • Received May 14, 2008
  • Revision received June 17, 2008
  • Accepted July 1, 2008
  • Published online September 1, 2008.

Copyright & Usage 
Copyright© 2008 International Institute of Anticaner Research (Dr. John G. Delinassios), All rights reserved

Author Information

  1. JOANN P. PALMA,
  2. LUIS E. RODRIGUEZ,
  3. VELITCHKA D. BONTCHEVA-DIAZ,
  4. JENNIFER J. BOUSKA,
  5. GAIL BUKOFZER,
  6. MILAGROS COLON-LOPEZ,
  7. RAN GUAN,
  8. KENNETH JARVIS,
  9. ERIC F. JOHNSON,
  10. VERED KLINGHOFER,
  11. XUESONG LIU,
  12. AMANDA OLSON,
  13. MARY J. SALTARELLI,
  14. YAN SHI,
  15. JASON A. STAVROPOULOS,
  16. GUI-DONG ZHU,
  17. THOMAS D. PENNING,
  18. YAN LUO,
  19. VINCENT L. GIRANDA,
  20. SAUL H. ROSENBERG,
  21. DAVID J. FROST and
  22. CHERRIE K. DONAWHO
  1. Abbott Laboratories, Cancer Research, Abbott Park, IL, 60064, U.S.A.
  1. Correspondence to: Cherrie K. Donawho, Abbott Laboratories, In Vivo Tumor Biology, Department R4N2, Bldg. AP3, Abbott Park, IL 60064, USA. Tel +1 8479376556, Fax: +1 8479384777, e-mail: cherrie.donawho{at}abbott.com

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The PARP Inhibitor, ABT-888 Potentiates Temozolomide: Correlation with Drug Levels and Reduction in PARP Activity In Vivo
JOANN P. PALMA, LUIS E. RODRIGUEZ, VELITCHKA D. BONTCHEVA-DIAZ, JENNIFER J. BOUSKA, GAIL BUKOFZER, MILAGROS COLON-LOPEZ, RAN GUAN, KENNETH JARVIS, ERIC F. JOHNSON, VERED KLINGHOFER, XUESONG LIU, AMANDA OLSON, MARY J. SALTARELLI, YAN SHI, JASON A. STAVROPOULOS, GUI-DONG ZHU, THOMAS D. PENNING, YAN LUO, VINCENT L. GIRANDA, SAUL H. ROSENBERG, DAVID J. FROST, CHERRIE K. DONAWHO
Anticancer Research Sep 2008, 28 (5A) 2625-2635;

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The PARP Inhibitor, ABT-888 Potentiates Temozolomide: Correlation with Drug Levels and Reduction in PARP Activity In Vivo
JOANN P. PALMA, LUIS E. RODRIGUEZ, VELITCHKA D. BONTCHEVA-DIAZ, JENNIFER J. BOUSKA, GAIL BUKOFZER, MILAGROS COLON-LOPEZ, RAN GUAN, KENNETH JARVIS, ERIC F. JOHNSON, VERED KLINGHOFER, XUESONG LIU, AMANDA OLSON, MARY J. SALTARELLI, YAN SHI, JASON A. STAVROPOULOS, GUI-DONG ZHU, THOMAS D. PENNING, YAN LUO, VINCENT L. GIRANDA, SAUL H. ROSENBERG, DAVID J. FROST, CHERRIE K. DONAWHO
Anticancer Research Sep 2008, 28 (5A) 2625-2635;
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