Skip to main content

Main menu

  • Home
  • Current Issue
  • Archive
  • Info for
    • Authors
    • Editorial Policies
    • Subscribers
    • Advertisers
    • Editorial Board
    • Special Issues 2025
  • Journal Metrics
  • Other Publications
    • In Vivo
    • Cancer Genomics & Proteomics
    • Cancer Diagnosis & Prognosis
  • More
    • IIAR
    • Conferences
    • 2008 Nobel Laureates
  • About Us
    • General Policy
    • Contact
  • Other Publications
    • Anticancer Research
    • In Vivo
    • Cancer Genomics & Proteomics

User menu

  • Register
  • Subscribe
  • My alerts
  • Log in
  • My Cart

Search

  • Advanced search
Anticancer Research
  • Other Publications
    • Anticancer Research
    • In Vivo
    • Cancer Genomics & Proteomics
  • Register
  • Subscribe
  • My alerts
  • Log in
  • My Cart
Anticancer Research

Advanced Search

  • Home
  • Current Issue
  • Archive
  • Info for
    • Authors
    • Editorial Policies
    • Subscribers
    • Advertisers
    • Editorial Board
    • Special Issues 2025
  • Journal Metrics
  • Other Publications
    • In Vivo
    • Cancer Genomics & Proteomics
    • Cancer Diagnosis & Prognosis
  • More
    • IIAR
    • Conferences
    • 2008 Nobel Laureates
  • About Us
    • General Policy
    • Contact
  • Visit us on Facebook
  • Follow us on Linkedin
Research ArticleClinical Studies

Expression of NLRP7 (PYPAF3, NALP7) Protein in Endometrial Cancer Tissues

SATOSHI OHNO, TAKESHI KINOSHITA, YUMIKO OHNO, TOSHINARI MINAMOTO, NOBUTAKA SUZUKI, MASAKI INOUE and TAKASHI SUDA
Anticancer Research July 2008, 28 (4C) 2493-2497;
SATOSHI OHNO
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • For correspondence: satoshio@med.kanazawa-u.ac.jp
TAKESHI KINOSHITA
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
YUMIKO OHNO
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
TOSHINARI MINAMOTO
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
NOBUTAKA SUZUKI
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
MASAKI INOUE
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
TAKASHI SUDA
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • Article
  • Info & Metrics
  • PDF
Loading

Abstract

Background: Nucleotide-binding domain and leucine-rich repeat-containing family, pyrin domain-containing 7 (NLRP7) (pyrin-containing apoptotic protease activating factor-1-like protein 3; PYPAF3, NACHT domain-, leucine-rich repeat, and pyrin domain-containing 7; NALP7) has been thought to contribute to innate immunity and inflammation. Although expression of NLRP7 in human seminoma tissues and several cancer cell lines has been demonstrated, the pathophysiological and prognostic importance in cancer tissues has not been defined. Materials and Methods: A series of 70 endometrial cancer cases that had undergone curative resection was studied to determine the correlation between NLRP7 expression and clinico-pathological characteristics in human endometrial cancer tissue. Tissue specimens were evaluated for NLRP7 by immunohistochemistry. Results: NLRP7 expression was positive in cancer cells in 7 cases (10%). There was a statistical relationship between the depth of tumor invasion and NLRP7 expression (p=0.0326). NLRP7 expression showed a trend for being associated with poor prognosis. Conclusion: Tumor-produced NLRP7, associated with myometrial invasion, might provide additional prognostic information in endometrial cancer patients.

  • NLRP7
  • immunohistochemistry
  • endometrial cancer
  • clinicopathological factors
  • prognosis

Footnotes

  • ↵* Both authors contributed equally to this work.

  • Received January 28, 2008.
  • Revision received April 22, 2008.
  • Accepted May 5, 2008.
  • Copyright© 2008 International Institute of Anticancer Research (Dr. John G. Delinassios), All rights reserved
PreviousNext
Back to top

In this issue

Anticancer Research: 28 (4C)
Anticancer Research
Vol. 28, Issue 4C
July-August 2008
  • Table of Contents
  • Table of Contents (PDF)
  • Index by author
  • Front Matter (PDF)
Download PDF
Article Alerts
Sign In to Email Alerts with your Email Address
Email Article

Thank you for your interest in spreading the word on Anticancer Research.

NOTE: We only request your email address so that the person you are recommending the page to knows that you wanted them to see it, and that it is not junk mail. We do not capture any email address.

Enter multiple addresses on separate lines or separate them with commas.
Expression of NLRP7 (PYPAF3, NALP7) Protein in Endometrial Cancer Tissues
(Your Name) has sent you a message from Anticancer Research
(Your Name) thought you would like to see the Anticancer Research web site.
CAPTCHA
This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.
3 + 8 =
Solve this simple math problem and enter the result. E.g. for 1+3, enter 4.
Citation Tools
Expression of NLRP7 (PYPAF3, NALP7) Protein in Endometrial Cancer Tissues
SATOSHI OHNO, TAKESHI KINOSHITA, YUMIKO OHNO, TOSHINARI MINAMOTO, NOBUTAKA SUZUKI, MASAKI INOUE, TAKASHI SUDA
Anticancer Research Jul 2008, 28 (4C) 2493-2497;

Citation Manager Formats

  • BibTeX
  • Bookends
  • EasyBib
  • EndNote (tagged)
  • EndNote 8 (xml)
  • Medlars
  • Mendeley
  • Papers
  • RefWorks Tagged
  • Ref Manager
  • RIS
  • Zotero
Reprints and Permissions
Share
Expression of NLRP7 (PYPAF3, NALP7) Protein in Endometrial Cancer Tissues
SATOSHI OHNO, TAKESHI KINOSHITA, YUMIKO OHNO, TOSHINARI MINAMOTO, NOBUTAKA SUZUKI, MASAKI INOUE, TAKASHI SUDA
Anticancer Research Jul 2008, 28 (4C) 2493-2497;
Twitter logo Facebook logo Mendeley logo
  • Tweet Widget
  • Facebook Like
  • Google Plus One

Jump to section

  • Article
  • Info & Metrics
  • PDF

Related Articles

  • No related articles found.
  • PubMed
  • Google Scholar

Cited By...

  • NOD-like receptors: major players (and targets) in the interface between innate immunity and cancer
  • NLRP7, a Nucleotide Oligomerization Domain-like Receptor Protein, Is Required for Normal Cytokine Secretion and Co-localizes with Golgi and the Microtubule-organizing Center
  • Three-dimensional Structure of the NLRP7 Pyrin Domain: INSIGHT INTO PYRIN-PYRIN-MEDIATED EFFECTOR DOMAIN SIGNALING IN INNATE IMMUNITY
  • Google Scholar

More in this TOC Section

  • Impact of Nivolumab Plus Chemotherapy on Conversion Therapy in Clinical Stage IVB HER2-negative Gastric Cancer
  • Treatment Outcomes After Progression With Enfortumab Vedotin in Patients With Advanced Urothelial Carcinoma
  • Rare Upper Mediastinal Oligometastasis from Early Esophagogastric Adenocarcinoma: A Case Report
Show more Clinical Studies

Similar Articles

Anticancer Research

© 2025 Anticancer Research

Powered by HighWire