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Research ArticleClinical Studies

Squamous-cell Carcinoma of the Anus with High Intratumoral Lymphocytosis and its Clinical Implications

CARLOS A. RUBIO and PER J. NILSSON
Anticancer Research July 2008, 28 (4C) 2469-2472;
CARLOS A. RUBIO
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  • For correspondence: Carlos.Rubio@ki.se
PER J. NILSSON
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Abstract

Background: It has been claimed that patients with squamous cell carcinoma of the anal canal (SCCAC) showing intraepithelial lymphocytes have a poor prognosis. Materials and Methods: The histological sections from 277 consecutive SCCAC were reviewed. Cases having a priori a high number of tumoral-intraepithelial lymphocytes (HTIL) were selected. The remaining cases showed only a few to none tumoral-intraepithelial lymphocytes. Results: Eight patients (all females) representing 3% of the 277 SCCAC had HTIL. All these 8 patients with SCCAC/HTIL had clinical stage II and III while these stages comprised 83% of the remaining SCCAC cases. Conclusion: Despite the 8 SCCAC/HTIL patients having a more advanced clinical stage than the remaining 269 SCCAC patients, these 8 patients had longer survival. Between 5 and 15 years follow-up, all SCCAC/HTIL patients had survived, whereas during the same time interval 28 (10.4%) of the SCCAC patients without HTIL had died of their tumor.

  • Squamous carcinoma
  • anal canal
  • intratumoral lymphocytes

Footnotes

  • Received March 5, 2008.
  • Revision received April 22, 2008.
  • Accepted April 30, 2008.
  • Copyright© 2008 International Institute of Anticancer Research (Dr. John G. Delinassios), All rights reserved
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Anticancer Research: 28 (4C)
Anticancer Research
Vol. 28, Issue 4C
July-August 2008
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Squamous-cell Carcinoma of the Anus with High Intratumoral Lymphocytosis and its Clinical Implications
CARLOS A. RUBIO, PER J. NILSSON
Anticancer Research Jul 2008, 28 (4C) 2469-2472;

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Squamous-cell Carcinoma of the Anus with High Intratumoral Lymphocytosis and its Clinical Implications
CARLOS A. RUBIO, PER J. NILSSON
Anticancer Research Jul 2008, 28 (4C) 2469-2472;
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