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Research ArticleClinical Studies

Cetuximab with Hepatic Arterial Infusion of Chemotherapy for the Treatment of Colorectal Cancer Liver Metastases

BART NEYNS, MARIDI AERTS, YVES VAN NIEUWENHOVE, CHRISTEL FONTAINE, LORE DE COSTER, DENNIS SCHALLIER, JACQUES VANDERAUWERA, FLORIS DE MUNCK, FREDERIK VANDENBROUCKE, HENDRIK EVERAERT, VANESSA MEERT, JOHAN DE MEY, MARK DE RIDDER, GEORGES DELVAUX and JACQUES DE GRÈVE
Anticancer Research July 2008, 28 (4C) 2459-2467;
BART NEYNS
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  • For correspondence: Bart.Neyns@uzbrussel.be
MARIDI AERTS
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YVES VAN NIEUWENHOVE
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CHRISTEL FONTAINE
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LORE DE COSTER
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DENNIS SCHALLIER
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JACQUES VANDERAUWERA
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FLORIS DE MUNCK
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FREDERIK VANDENBROUCKE
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HENDRIK EVERAERT
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VANESSA MEERT
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JOHAN DE MEY
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MARK DE RIDDER
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GEORGES DELVAUX
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JACQUES DE GRÈVE
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Abstract

Background: Both hepatic arterial infusion (HAI) of chemotherapy and cetuximab (CET) have interesting activity for the treatment of colorectal cancer liver metastases (CRC-LM). Patients and Methods: Intravenous CET with HAI oxaliplatin (OXA) or i.v. Irinotecan (IRI) followed by HAI of infusion of folic acid modulated 5-fluorouracil 5-FU/l-FA was administered to patients (pts) with CRC-LM who had failed at least one line of prior chemotherapy. Results: Eight pts received i.v. CET with HAI-OXA (5 pts) and i.v.-IRI (3 pts) and HAI-5-FU/l-FA. Adverse events: repeated grade 3 skin toxicity (1 pt), abdominal pain with elevated liver enzymes and asthenia (2 pts), duodenal ulcer (2 pts) with catheter migration and intestinal bleeding (1 pt), reversible interstitial pneumonitis (1 pt), and cystic bile duct dilatation (2 pts) with arteriobiliary fistulisation (1 pt). A partial response was documented in 5 pts (62%). The median time to progression was 8.7 months (95% confidence interval 8-14 months). Conclusion: Intravenous administration of CET with HAI of chemotherapy is feasible and has promising activity but is associated with specific toxicity.

  • 5-Fluorouracil
  • arterial
  • infusion
  • cetuximab
  • colorectal
  • irinotecan
  • oxaliplatin
  • metastases

Footnotes

  • Received February 20, 2008.
  • Revision received May 28, 2008.
  • Accepted June 2, 2008.
  • Copyright© 2008 International Institute of Anticancer Research (Dr. John G. Delinassios), All rights reserved
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Anticancer Research: 28 (4C)
Anticancer Research
Vol. 28, Issue 4C
July-August 2008
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Cetuximab with Hepatic Arterial Infusion of Chemotherapy for the Treatment of Colorectal Cancer Liver Metastases
BART NEYNS, MARIDI AERTS, YVES VAN NIEUWENHOVE, CHRISTEL FONTAINE, LORE DE COSTER, DENNIS SCHALLIER, JACQUES VANDERAUWERA, FLORIS DE MUNCK, FREDERIK VANDENBROUCKE, HENDRIK EVERAERT, VANESSA MEERT, JOHAN DE MEY, MARK DE RIDDER, GEORGES DELVAUX, JACQUES DE GRÈVE
Anticancer Research Jul 2008, 28 (4C) 2459-2467;

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Cetuximab with Hepatic Arterial Infusion of Chemotherapy for the Treatment of Colorectal Cancer Liver Metastases
BART NEYNS, MARIDI AERTS, YVES VAN NIEUWENHOVE, CHRISTEL FONTAINE, LORE DE COSTER, DENNIS SCHALLIER, JACQUES VANDERAUWERA, FLORIS DE MUNCK, FREDERIK VANDENBROUCKE, HENDRIK EVERAERT, VANESSA MEERT, JOHAN DE MEY, MARK DE RIDDER, GEORGES DELVAUX, JACQUES DE GRÈVE
Anticancer Research Jul 2008, 28 (4C) 2459-2467;
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