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Research ArticleClinical Studies

Pregnancy and Post-partum Breast Cancer: A Prospective Study

CAROLE MATHELIN, KADOUR ANNANE, ALAIN TREISSER, MARIE-PIERRE CHENARD, CATHERINE TOMASETTO, JEAN-PIERRE BELLOCQ and MARIE-CHRISTINE RIO
Anticancer Research July 2008, 28 (4C) 2447-2452;
CAROLE MATHELIN
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KADOUR ANNANE
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ALAIN TREISSER
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MARIE-PIERRE CHENARD
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CATHERINE TOMASETTO
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JEAN-PIERRE BELLOCQ
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MARIE-CHRISTINE RIO
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  • For correspondence: rio@titus.u-strasbg.fr
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Abstract

Background: The concomitant occurrence of breast cancer and pregnancy remains a challenging clinical situation combining ethical and medical problems. There are few prospective data on pregnancy-associated breast cancer (PABC) whose incidence continuously increases. Patients and Methods: Forty patients with PABC were compared with 61 non-pregnant, age-matched patients with infiltrative breast carcinomas (BC) diagnosed and followed since 1982. Results: Although PABC and BC tumor size, grade and type, and lymphovascular and lymphnode invasion were similar, the BC cases showed better overall- (p=0.0001) and disease-free (p=0.015) survival. Moreover, the outcome of pregnant patients was worse than post-partum patients (p=0.017). Importantly, the number of PABC patients receiving hormonotherapy was lower than the BC patients (p<0.0004), due to lower estrogen receptor (ER) (p=0.038) and progesterone receptor (PR) (p=0.008) immunohisto-chemical (IH) levels. Retrospective estrogen-regulated pS2/trefoil factor 1 (pS2/TFF1) immunohistochemitry showed no difference between PABC and BC. All the children delivered were healthy. Conclusion: Pregnancy and the post-partum period increase breast cancer aggressiveness, pregnancy being the most detrimental. PABC hormone-dependence is under-estimated using ER and PR, and pS2/TFF1 might help in its determination. Appropriate treatment does not impair child outcome.

  • Breast cancer
  • pregnancy
  • hormonotherapy
  • patient outcome
  • child outcome

Footnotes

  • Received February 29, 2008.
  • Revision received April 16, 2008.
  • Accepted April 21, 2008.
  • Copyright© 2008 International Institute of Anticancer Research (Dr. John G. Delinassios), All rights reserved
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Anticancer Research: 28 (4C)
Anticancer Research
Vol. 28, Issue 4C
July-August 2008
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Pregnancy and Post-partum Breast Cancer: A Prospective Study
CAROLE MATHELIN, KADOUR ANNANE, ALAIN TREISSER, MARIE-PIERRE CHENARD, CATHERINE TOMASETTO, JEAN-PIERRE BELLOCQ, MARIE-CHRISTINE RIO
Anticancer Research Jul 2008, 28 (4C) 2447-2452;

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Pregnancy and Post-partum Breast Cancer: A Prospective Study
CAROLE MATHELIN, KADOUR ANNANE, ALAIN TREISSER, MARIE-PIERRE CHENARD, CATHERINE TOMASETTO, JEAN-PIERRE BELLOCQ, MARIE-CHRISTINE RIO
Anticancer Research Jul 2008, 28 (4C) 2447-2452;
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