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Research ArticleClinical Studies

Clonazepam for Chemotherapy-induced Nausea and Vomiting (CINV)

MINAKO KOGA, MOMOE NAKADOZONO, KAZUTAKA NUKARIYA, HIROKO NOGI, TADASHI KOBAYASHI and KAZUHIKO NAKAYAMA
Anticancer Research July 2008, 28 (4C) 2433-2436;
MINAKO KOGA
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  • For correspondence: mi-na@pd5.so-net.ne.jp mi-na@jikei.ac.jp
MOMOE NAKADOZONO
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KAZUTAKA NUKARIYA
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HIROKO NOGI
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TADASHI KOBAYASHI
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KAZUHIKO NAKAYAMA
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Abstract

Background: A 51-year-old woman experienced refractory chemotherapy-induced nausea and vomiting (CINV) in spite of extensive antiemetic therapy, including 5-HT3 antagonists, corticosteroids, dopamine antagonists and antihistamines. Case Report: We administered the patient clonazepam. After taking clonazepam, the patient fully recovered from the nausea and vomiting and never experienced them again. Conclusion: Clonazepam may be useful in the control of CINV. We believe that clonazepam contributed to the favorable outcome by expressing an anxiolytic and an anticonvulsant effect on myoclonus. The efficacy of clonazepam in this indication of prevention of CINV warrants further investigation.

  • Clonazepam
  • chemotherapy-induced nausea and vomiting (CINV)
  • antiemesis
  • benzodiazepines
  • anticonvulsant

Footnotes

  • Received February 8, 2008.
  • Revision received April 15, 2008.
  • Accepted April 21, 2008.
  • Copyright© 2008 International Institute of Anticancer Research (Dr. John G. Delinassios), All rights reserved
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Anticancer Research: 28 (4C)
Anticancer Research
Vol. 28, Issue 4C
July-August 2008
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Clonazepam for Chemotherapy-induced Nausea and Vomiting (CINV)
MINAKO KOGA, MOMOE NAKADOZONO, KAZUTAKA NUKARIYA, HIROKO NOGI, TADASHI KOBAYASHI, KAZUHIKO NAKAYAMA
Anticancer Research Jul 2008, 28 (4C) 2433-2436;

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Clonazepam for Chemotherapy-induced Nausea and Vomiting (CINV)
MINAKO KOGA, MOMOE NAKADOZONO, KAZUTAKA NUKARIYA, HIROKO NOGI, TADASHI KOBAYASHI, KAZUHIKO NAKAYAMA
Anticancer Research Jul 2008, 28 (4C) 2433-2436;
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