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Research ArticleClinical Studies

Urinary Neopterin, Hemoglobin and Peripheral Blood Cell Counts in Breast Carcinoma Patients Treated with Dose-dense Chemotherapy

BOHUSLAV MELICHAR, LUBOR URBÁNEK, LENKA KRČMOVÁ, HANA KALÁBOVÁ, KAROLINA MELICHAROVÁ, EVA MALÍŘOVÁ, HELENA HORNYCHOVÁ, ALEŠ RYŠKA, RADOMÍR HYŠPLER and DAGMAR SOLICHOVÁ
Anticancer Research July 2008, 28 (4C) 2389-2396;
BOHUSLAV MELICHAR
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  • For correspondence: bohuslav.melichar@fnol.cz
LUBOR URBÁNEK
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LENKA KRČMOVÁ
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HANA KALÁBOVÁ
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KAROLINA MELICHAROVÁ
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EVA MALÍŘOVÁ
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HELENA HORNYCHOVÁ
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ALEŠ RYŠKA
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RADOMÍR HYŠPLER
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DAGMAR SOLICHOVÁ
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Abstract

Background: Among other actions, chemotherapy may induce an activation of systemic inflammatory and immune response. Patients and Methods: Urinary neopterin was evaluated, using high-performance liquid chromatography, before and during dose-dense combination chemotherapy with doxorubicin, cyclophosphamide and sequential paclitaxel (neoadjuvant or adjuvant) in 194 patients with breast carcinoma. Hemoglobin, peripheral blood cell count and, in a subgroup of patients, iron metabolism were also evaluated. Results: Urinary neopterin increased significantly during the chemotherapy. The increase in urinary neopterin was accompanied by a gradual decrease of hemoglobin. A marked increase in serum ferritin concentration was observed during the chemotherapy, along with fluctuations of iron concentrations. Among 161 patients treated with primary chemotherapy, the pathological response was evaluable in 150. Pathological complete response was observed in 37 cases (25%). In patients with pathological complete response, significantly lower serum ferritin concentrations were observed. Conclusion: Present data demonstrate the presence of systemic immune activation, reflected in increased urinary neopterin concentrations, in breast carcinoma patients treated with dose-dense chemotherapy. Lower ferritin concentrations were predictive of pathological complete response.

  • Breast carcinoma
  • chemotherapy
  • cyclophosphamide
  • doxorubicin
  • ferritin
  • iron
  • neopterin
  • paclitaxel

Footnotes

  • Received March 4, 2008.
  • Revision received May 22, 2008.
  • Accepted May 26, 2008.
  • Copyright© 2008 International Institute of Anticancer Research (Dr. John G. Delinassios), All rights reserved
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Anticancer Research: 28 (4C)
Anticancer Research
Vol. 28, Issue 4C
July-August 2008
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Urinary Neopterin, Hemoglobin and Peripheral Blood Cell Counts in Breast Carcinoma Patients Treated with Dose-dense Chemotherapy
BOHUSLAV MELICHAR, LUBOR URBÁNEK, LENKA KRČMOVÁ, HANA KALÁBOVÁ, KAROLINA MELICHAROVÁ, EVA MALÍŘOVÁ, HELENA HORNYCHOVÁ, ALEŠ RYŠKA, RADOMÍR HYŠPLER, DAGMAR SOLICHOVÁ
Anticancer Research Jul 2008, 28 (4C) 2389-2396;

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Urinary Neopterin, Hemoglobin and Peripheral Blood Cell Counts in Breast Carcinoma Patients Treated with Dose-dense Chemotherapy
BOHUSLAV MELICHAR, LUBOR URBÁNEK, LENKA KRČMOVÁ, HANA KALÁBOVÁ, KAROLINA MELICHAROVÁ, EVA MALÍŘOVÁ, HELENA HORNYCHOVÁ, ALEŠ RYŠKA, RADOMÍR HYŠPLER, DAGMAR SOLICHOVÁ
Anticancer Research Jul 2008, 28 (4C) 2389-2396;
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