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Research ArticleClinical Studies

The Significance of Gastrectomy in Advanced Gastric Cancer Patients with Non-curative Factors

H. MIYAGAKI, K. FUJITANI, T. TSUJINAKA, M. HIRAO, M. YASUI, M. KASHIWAZAKI, M. IKENAGA, M. MIYAZAKI, H. MISHIMA and S. NAKAMORI
Anticancer Research July 2008, 28 (4C) 2379-2384;
H. MIYAGAKI
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K. FUJITANI
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  • For correspondence: fujitani@onh.go.jp
T. TSUJINAKA
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M. HIRAO
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M. YASUI
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M. KASHIWAZAKI
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M. IKENAGA
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M. MIYAZAKI
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H. MISHIMA
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S. NAKAMORI
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Abstract

Background: The role of gastrectomy in the treatment of advanced gastric cancer patients with non-curative factors remains controversial. We investigated prognostic factors and evaluated the role of gastrectomy in such patients. Patients and Methods: Eighty-eight advanced gastric cancer patients with non-curative factors were prospectively studied. The patients were categorized into the following two groups: Group A: 52 patients who underwent gastrectomy and subsequently received chemotherapy, Group B: 36 patients who received chemotherapy alone. Results: The median survival times of group A and B patients were 351 and 182 days, respectively (p=0.008). Multivariate analysis showed that gastrectomy was the only positive independent prognostic factor, with no effect on the results of chemotherapy. There was no significant difference in the duration of hospital stay between patients of the two groups, while significantly longer maintenance of oral intake was observed for group A. Conclusion: In advanced gastric cancer patients with non-curative factors, gastrectomy was beneficial for survival with longer maintenance of oral intake.

  • Gastrectomy
  • non-curative factor
  • prognostic factor
  • advanced gastric cancer

Footnotes

  • Received February 11, 2008.
  • Revision received April 8, 2008.
  • Accepted May 2, 2008.
  • Copyright© 2008 International Institute of Anticancer Research (Dr. John G. Delinassios), All rights reserved
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Anticancer Research: 28 (4C)
Anticancer Research
Vol. 28, Issue 4C
July-August 2008
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The Significance of Gastrectomy in Advanced Gastric Cancer Patients with Non-curative Factors
H. MIYAGAKI, K. FUJITANI, T. TSUJINAKA, M. HIRAO, M. YASUI, M. KASHIWAZAKI, M. IKENAGA, M. MIYAZAKI, H. MISHIMA, S. NAKAMORI
Anticancer Research Jul 2008, 28 (4C) 2379-2384;

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The Significance of Gastrectomy in Advanced Gastric Cancer Patients with Non-curative Factors
H. MIYAGAKI, K. FUJITANI, T. TSUJINAKA, M. HIRAO, M. YASUI, M. KASHIWAZAKI, M. IKENAGA, M. MIYAZAKI, H. MISHIMA, S. NAKAMORI
Anticancer Research Jul 2008, 28 (4C) 2379-2384;
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