Skip to main content

Main menu

  • Home
  • Current Issue
  • Archive
  • Info for
    • Authors
    • Editorial Policies
    • Subscribers
    • Advertisers
    • Editorial Board
    • Special Issues 2025
  • Journal Metrics
  • Other Publications
    • In Vivo
    • Cancer Genomics & Proteomics
    • Cancer Diagnosis & Prognosis
  • More
    • IIAR
    • Conferences
    • 2008 Nobel Laureates
  • About Us
    • General Policy
    • Contact
  • Other Publications
    • Anticancer Research
    • In Vivo
    • Cancer Genomics & Proteomics

User menu

  • Register
  • Subscribe
  • My alerts
  • Log in
  • My Cart

Search

  • Advanced search
Anticancer Research
  • Other Publications
    • Anticancer Research
    • In Vivo
    • Cancer Genomics & Proteomics
  • Register
  • Subscribe
  • My alerts
  • Log in
  • My Cart
Anticancer Research

Advanced Search

  • Home
  • Current Issue
  • Archive
  • Info for
    • Authors
    • Editorial Policies
    • Subscribers
    • Advertisers
    • Editorial Board
    • Special Issues 2025
  • Journal Metrics
  • Other Publications
    • In Vivo
    • Cancer Genomics & Proteomics
    • Cancer Diagnosis & Prognosis
  • More
    • IIAR
    • Conferences
    • 2008 Nobel Laureates
  • About Us
    • General Policy
    • Contact
  • Visit us on Facebook
  • Follow us on Linkedin
Research ArticleClinical Studies

The Impact of Surgical Treatment and Poor Prognostic Factors for Patients with Intrahepatic Cholangiocarcinoma: Retrospective Analysis of 60 Patients

YO-ICHI YAMASHITA, AKINOBU TAKETOMI, KAZUTOYO MORITA, TAKASUKE FUKUHARA, SHIGERU UEDA, KENSAKU SANEFUJI, TOMOHIRO IGUCHI, HIROTO KAYASHIMA, KEISHI SUGIMACHI and YOSHIHIKO MAEHARA
Anticancer Research July 2008, 28 (4C) 2353-2359;
YO-ICHI YAMASHITA
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • For correspondence: yamashi@surg2.med.kyushu-u.ac.jp
AKINOBU TAKETOMI
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
KAZUTOYO MORITA
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
TAKASUKE FUKUHARA
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
SHIGERU UEDA
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
KENSAKU SANEFUJI
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
TOMOHIRO IGUCHI
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
HIROTO KAYASHIMA
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
KEISHI SUGIMACHI
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
YOSHIHIKO MAEHARA
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • Article
  • Info & Metrics
  • PDF
Loading

Abstract

Background: Intrahepatic cholangiocarcinoma (ICC) is a primary adenocarcinoma of the liver arising from the intrahepatic bile duct. Hepatectomy with extensive lymph node dissection is the standard treatment for ICC. Patients and Methods: Sixty patients with ICC who underwent hepatectomy in our institution between 1986 and 2005 were investigated to determine prognostic factors and to evaluate the impact of surgical treatment for ICC using univariate and multivariate analyses. Results: The overall survival rate of the R0 resection group (n=43) was significantly higher than that of the R1/2 group (n=17). However, in patients with lymph node metastasis (n=24), R0 resection had no survival impact. According to multivariate analysis, the independent factors of poor prognosis were: the presence of lymph node metastasis, lymphatic invasion, poor differentiation and R1/2 resection. Conclusion: R0 resection can provide prolonged survival for patients with ICC. Patients with lymph node metastasis, lymphatic invasion, or poorly differentiated ICC have poor prognosis after operation and additional treatment, such as adjuvant chemotherapy, is recommended.

  • Intrahepatic cholangiocarcinoma
  • R0 resection
  • lymph node dissection
  • poor prognostic factors

Footnotes

  • Received January 18, 2008.
  • Revision received March 18, 2008.
  • Accepted March 26, 2008.
  • Copyright© 2008 International Institute of Anticancer Research (Dr. John G. Delinassios), All rights reserved
PreviousNext
Back to top

In this issue

Anticancer Research: 28 (4C)
Anticancer Research
Vol. 28, Issue 4C
July-August 2008
  • Table of Contents
  • Table of Contents (PDF)
  • Index by author
  • Front Matter (PDF)
Download PDF
Article Alerts
Sign In to Email Alerts with your Email Address
Email Article

Thank you for your interest in spreading the word on Anticancer Research.

NOTE: We only request your email address so that the person you are recommending the page to knows that you wanted them to see it, and that it is not junk mail. We do not capture any email address.

Enter multiple addresses on separate lines or separate them with commas.
The Impact of Surgical Treatment and Poor Prognostic Factors for Patients with Intrahepatic Cholangiocarcinoma: Retrospective Analysis of 60 Patients
(Your Name) has sent you a message from Anticancer Research
(Your Name) thought you would like to see the Anticancer Research web site.
CAPTCHA
This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.
9 + 7 =
Solve this simple math problem and enter the result. E.g. for 1+3, enter 4.
Citation Tools
The Impact of Surgical Treatment and Poor Prognostic Factors for Patients with Intrahepatic Cholangiocarcinoma: Retrospective Analysis of 60 Patients
YO-ICHI YAMASHITA, AKINOBU TAKETOMI, KAZUTOYO MORITA, TAKASUKE FUKUHARA, SHIGERU UEDA, KENSAKU SANEFUJI, TOMOHIRO IGUCHI, HIROTO KAYASHIMA, KEISHI SUGIMACHI, YOSHIHIKO MAEHARA
Anticancer Research Jul 2008, 28 (4C) 2353-2359;

Citation Manager Formats

  • BibTeX
  • Bookends
  • EasyBib
  • EndNote (tagged)
  • EndNote 8 (xml)
  • Medlars
  • Mendeley
  • Papers
  • RefWorks Tagged
  • Ref Manager
  • RIS
  • Zotero
Reprints and Permissions
Share
The Impact of Surgical Treatment and Poor Prognostic Factors for Patients with Intrahepatic Cholangiocarcinoma: Retrospective Analysis of 60 Patients
YO-ICHI YAMASHITA, AKINOBU TAKETOMI, KAZUTOYO MORITA, TAKASUKE FUKUHARA, SHIGERU UEDA, KENSAKU SANEFUJI, TOMOHIRO IGUCHI, HIROTO KAYASHIMA, KEISHI SUGIMACHI, YOSHIHIKO MAEHARA
Anticancer Research Jul 2008, 28 (4C) 2353-2359;
Twitter logo Facebook logo Mendeley logo
  • Tweet Widget
  • Facebook Like
  • Google Plus One

Jump to section

  • Article
  • Info & Metrics
  • PDF

Related Articles

  • No related articles found.
  • PubMed
  • Google Scholar

Cited By...

  • Clinical Usefulness of Perioperative C-reactive Protein/Albumin Ratio in Patients With Intrahepatic Cholangiocarcinoma: A Retrospective Single Institutional Study
  • Predictors of Cure of Intrahepatic Cholangiocarcinoma After Hepatic Resection
  • Impact and Prediction of Lymph Node Involvement in Patients with Intrahepatic Cholangiocarcinoma After Curative Resection
  • Clinical Benefits of Lymph Node Dissection in Intrahepatic Cholangiocarcinoma: A Retrospective Single-institution Study
  • Clinical Significances of Preoperative Classification of Intrahepatic Cholangiocarcinoma: Different Characteristics of Perihilar vs. Peripheral ICC
  • Google Scholar

More in this TOC Section

  • Radiomics for Growth Prediction of Vestibular Schwannomas in Neurofibromatosis Type 2
  • Chemotherapy-induced Moderate to Severe Peripheral Neuropathy in Patients Receiving Adjuvant Radiotherapy for Breast Cancer
  • Efficacy and Prognostic Factors of Surgical Resection for Pulmonary Metastases From Ovarian Cancer
Show more Clinical Studies

Similar Articles

Anticancer Research

© 2025 Anticancer Research

Powered by HighWire