Skip to main content

Main menu

  • Home
  • Current Issue
  • Archive
  • Info for
    • Authors
    • Editorial Policies
    • Subscribers
    • Advertisers
    • Editorial Board
    • Special Issues 2025
  • Journal Metrics
  • Other Publications
    • In Vivo
    • Cancer Genomics & Proteomics
    • Cancer Diagnosis & Prognosis
  • More
    • IIAR
    • Conferences
    • 2008 Nobel Laureates
  • About Us
    • General Policy
    • Contact
  • Other Publications
    • Anticancer Research
    • In Vivo
    • Cancer Genomics & Proteomics

User menu

  • Register
  • Subscribe
  • My alerts
  • Log in
  • My Cart

Search

  • Advanced search
Anticancer Research
  • Other Publications
    • Anticancer Research
    • In Vivo
    • Cancer Genomics & Proteomics
  • Register
  • Subscribe
  • My alerts
  • Log in
  • My Cart
Anticancer Research

Advanced Search

  • Home
  • Current Issue
  • Archive
  • Info for
    • Authors
    • Editorial Policies
    • Subscribers
    • Advertisers
    • Editorial Board
    • Special Issues 2025
  • Journal Metrics
  • Other Publications
    • In Vivo
    • Cancer Genomics & Proteomics
    • Cancer Diagnosis & Prognosis
  • More
    • IIAR
    • Conferences
    • 2008 Nobel Laureates
  • About Us
    • General Policy
    • Contact
  • Visit us on Facebook
  • Follow us on Linkedin
Research ArticleClinical Studies

Clinical Significance and Pathogenic Function of Connective Tissue Growth Factor (CTGF/CCN2) in Osteolytic Mandibular Squamous Cell Carcinoma

TSUYOSHI SHIMO, SATOSHI KUBOTA, TAKESHI GODA, YASUTO YOSHIHAMA, NAITO KURIO, TAKASHI NISHIDA, POH-SING NG, KOKI ENDO, MASAHARU TAKIGAWA and AKIRA SASAKI
Anticancer Research July 2008, 28 (4C) 2343-2348;
TSUYOSHI SHIMO
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • For correspondence: shimotsu@md.okayama-u.ac.jp
SATOSHI KUBOTA
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
TAKESHI GODA
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
YASUTO YOSHIHAMA
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
NAITO KURIO
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
TAKASHI NISHIDA
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
POH-SING NG
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
KOKI ENDO
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
MASAHARU TAKIGAWA
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
AKIRA SASAKI
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • Article
  • Info & Metrics
  • PDF
Loading

Abstract

Background: Mandibular bone destruction is a frequent occurrence in oral squamous cell carcinoma. However, the relationship between the bone destruction and associated factors is unclear. Here, the role and diagnostic utility of connective tissue growth factor (CCN2) in bone destruction of the mandible was investigated. Patients and Methods: The production of CCN2 was explored by using immunohistochemistry on paraffin-embedded tissues from 20 cases of mandibular squamous cell carcinoma. The effect of CCN2 on osteoclastogenesis was examined in vitro by using total bone marrow cell populations from male mice. Results: Immunohistochemical analysis showed that CCN2-positive signals were closely associated with destructive invasion of the mandible by oral squamous cell carcinomas. Consistent with these results, recombinant human CCN2 (rCCN2) stimulated tartrate-resistant acid phosphatase (TRAP)-positive osteoclast-like cell formation in vitro. Conclusion: CCN2 can be considered a diagnostic marker and target for treatment in oral osteolytic mandibular squamous cell carcinoma.

  • Mandibular bone destruction
  • CCN2
  • osteoclast

Footnotes

  • Received February 5, 2008.
  • Revision received May 2, 2008.
  • Accepted May 9, 2008.
  • Copyright© 2008 International Institute of Anticancer Research (Dr. John G. Delinassios), All rights reserved
PreviousNext
Back to top

In this issue

Anticancer Research: 28 (4C)
Anticancer Research
Vol. 28, Issue 4C
July-August 2008
  • Table of Contents
  • Table of Contents (PDF)
  • Index by author
  • Front Matter (PDF)
Download PDF
Article Alerts
Sign In to Email Alerts with your Email Address
Email Article

Thank you for your interest in spreading the word on Anticancer Research.

NOTE: We only request your email address so that the person you are recommending the page to knows that you wanted them to see it, and that it is not junk mail. We do not capture any email address.

Enter multiple addresses on separate lines or separate them with commas.
Clinical Significance and Pathogenic Function of Connective Tissue Growth Factor (CTGF/CCN2) in Osteolytic Mandibular Squamous Cell Carcinoma
(Your Name) has sent you a message from Anticancer Research
(Your Name) thought you would like to see the Anticancer Research web site.
CAPTCHA
This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.
3 + 0 =
Solve this simple math problem and enter the result. E.g. for 1+3, enter 4.
Citation Tools
Clinical Significance and Pathogenic Function of Connective Tissue Growth Factor (CTGF/CCN2) in Osteolytic Mandibular Squamous Cell Carcinoma
TSUYOSHI SHIMO, SATOSHI KUBOTA, TAKESHI GODA, YASUTO YOSHIHAMA, NAITO KURIO, TAKASHI NISHIDA, POH-SING NG, KOKI ENDO, MASAHARU TAKIGAWA, AKIRA SASAKI
Anticancer Research Jul 2008, 28 (4C) 2343-2348;

Citation Manager Formats

  • BibTeX
  • Bookends
  • EasyBib
  • EndNote (tagged)
  • EndNote 8 (xml)
  • Medlars
  • Mendeley
  • Papers
  • RefWorks Tagged
  • Ref Manager
  • RIS
  • Zotero
Reprints and Permissions
Share
Clinical Significance and Pathogenic Function of Connective Tissue Growth Factor (CTGF/CCN2) in Osteolytic Mandibular Squamous Cell Carcinoma
TSUYOSHI SHIMO, SATOSHI KUBOTA, TAKESHI GODA, YASUTO YOSHIHAMA, NAITO KURIO, TAKASHI NISHIDA, POH-SING NG, KOKI ENDO, MASAHARU TAKIGAWA, AKIRA SASAKI
Anticancer Research Jul 2008, 28 (4C) 2343-2348;
Twitter logo Facebook logo Mendeley logo
  • Tweet Widget
  • Facebook Like
  • Google Plus One

Jump to section

  • Article
  • Info & Metrics
  • PDF

Related Articles

  • No related articles found.
  • PubMed
  • Google Scholar

Cited By...

  • The Prognostic Implications of Bone Invasion in Gingival Squamous Cell Carcinoma
  • Bone Destruction by Invading Oral Squamous Carcinoma Cells Mediated by the Transforming Growth Factor-{beta} Signalling Pathway
  • Google Scholar

More in this TOC Section

  • Impact of Nivolumab Plus Chemotherapy on Conversion Therapy in Clinical Stage IVB HER2-negative Gastric Cancer
  • Treatment Outcomes After Progression With Enfortumab Vedotin in Patients With Advanced Urothelial Carcinoma
  • Rare Upper Mediastinal Oligometastasis from Early Esophagogastric Adenocarcinoma: A Case Report
Show more Clinical Studies

Similar Articles

Anticancer Research

© 2025 Anticancer Research

Powered by HighWire