Skip to main content

Main menu

  • Home
  • Current Issue
  • Archive
  • Info for
    • Authors
    • Editorial Policies
    • Subscribers
    • Advertisers
    • Editorial Board
    • Special Issues 2025
  • Journal Metrics
  • Other Publications
    • In Vivo
    • Cancer Genomics & Proteomics
    • Cancer Diagnosis & Prognosis
  • More
    • IIAR
    • Conferences
    • 2008 Nobel Laureates
  • About Us
    • General Policy
    • Contact
  • Other Publications
    • Anticancer Research
    • In Vivo
    • Cancer Genomics & Proteomics

User menu

  • Register
  • Subscribe
  • My alerts
  • Log in
  • My Cart

Search

  • Advanced search
Anticancer Research
  • Other Publications
    • Anticancer Research
    • In Vivo
    • Cancer Genomics & Proteomics
  • Register
  • Subscribe
  • My alerts
  • Log in
  • My Cart
Anticancer Research

Advanced Search

  • Home
  • Current Issue
  • Archive
  • Info for
    • Authors
    • Editorial Policies
    • Subscribers
    • Advertisers
    • Editorial Board
    • Special Issues 2025
  • Journal Metrics
  • Other Publications
    • In Vivo
    • Cancer Genomics & Proteomics
    • Cancer Diagnosis & Prognosis
  • More
    • IIAR
    • Conferences
    • 2008 Nobel Laureates
  • About Us
    • General Policy
    • Contact
  • Visit us on Facebook
  • Follow us on Linkedin
Research ArticleExperimental Studies

The Growth-promoting Action of Individual Women's Sera on Mammary Carcinoma Cells

DORIS AUER, MICHAEL HUBALEK, MARTINA FLEISCHER, JULIA ROESSLER and GUENTER DAXENBICHLER
Anticancer Research July 2008, 28 (4B) 2213-2217;
DORIS AUER
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
MICHAEL HUBALEK
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
MARTINA FLEISCHER
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
JULIA ROESSLER
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
GUENTER DAXENBICHLER
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • For correspondence: guenter.daxenbichler@i-med.ac.at
  • Article
  • Info & Metrics
  • PDF
Loading

Abstract

In vitro studies concerning the growth-stimulating effect of hormones, especially of estradiol and its metabolites, have mainly been performed using pure substances and breast cancer cell lines. In order to take into account the metabolism of inactive into active hormones or drugs and vice versa which occurs in several tissues, the influence of individual patients' sera on the growth of breast cancer cells in vitro was tested. Besides measuring the growth promoting action of several hormone replacement therapies, the antiestrogenic effect was determined by measuring the effect of 10-10 M estradiol added to the culture medium (E2-sensitivity). Influence on proliferation and stimulatability was similar in MCF-7 and T47-D cells. Growth-promoting potential correlated significantly with patient age, being higher in young ladies than in older ones. The converse was true for E2 sensitivity. From the different steroid hormones tested, only higher estradiol levels were associated with increased growth stimulation and diminished E2 sensitivity. Hormone replacement therapy (HRT) of different types did not significantly increase growth potential of serum, however these results are preliminary. Treatment with tamoxifen of breast cancer patients led to a decrease of E2 sensitivity, whereas growth potential was not affected significantly. For the aromatase inhibitor Arimidex, a tendency towards growth inhibition and increased E2 sensitivity was observed. Our in vitro system allows identifying differences between individual persons and groups of women of different age or treatment with respect to stimulation of growth or influence on estrogen sensitivity of breast cancer cells by serum. It is speculated that results might reflect the personal risk or the risk under treatment to develop breast cancer.

  • Breast cancer
  • steroids
  • in vitro assay
  • MCF-7
  • tamoxifen

Footnotes

  • Received January 10, 2008.
  • Revision received May 28, 2008.
  • Accepted June 2, 2008.
  • Copyright© 2008 International Institute of Anticancer Research (Dr. John G. Delinassios), All rights reserved
PreviousNext
Back to top

In this issue

Anticancer Research: 28 (4B)
Anticancer Research
Vol. 28, Issue 4B
July-August 2008
  • Table of Contents
  • Table of Contents (PDF)
  • Index by author
  • Front Matter (PDF)
Download PDF
Article Alerts
Sign In to Email Alerts with your Email Address
Email Article

Thank you for your interest in spreading the word on Anticancer Research.

NOTE: We only request your email address so that the person you are recommending the page to knows that you wanted them to see it, and that it is not junk mail. We do not capture any email address.

Enter multiple addresses on separate lines or separate them with commas.
The Growth-promoting Action of Individual Women's Sera on Mammary Carcinoma Cells
(Your Name) has sent you a message from Anticancer Research
(Your Name) thought you would like to see the Anticancer Research web site.
CAPTCHA
This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.
3 + 16 =
Solve this simple math problem and enter the result. E.g. for 1+3, enter 4.
Citation Tools
The Growth-promoting Action of Individual Women's Sera on Mammary Carcinoma Cells
DORIS AUER, MICHAEL HUBALEK, MARTINA FLEISCHER, JULIA ROESSLER, GUENTER DAXENBICHLER
Anticancer Research Jul 2008, 28 (4B) 2213-2217;

Citation Manager Formats

  • BibTeX
  • Bookends
  • EasyBib
  • EndNote (tagged)
  • EndNote 8 (xml)
  • Medlars
  • Mendeley
  • Papers
  • RefWorks Tagged
  • Ref Manager
  • RIS
  • Zotero
Reprints and Permissions
Share
The Growth-promoting Action of Individual Women's Sera on Mammary Carcinoma Cells
DORIS AUER, MICHAEL HUBALEK, MARTINA FLEISCHER, JULIA ROESSLER, GUENTER DAXENBICHLER
Anticancer Research Jul 2008, 28 (4B) 2213-2217;
Twitter logo Facebook logo Mendeley logo
  • Tweet Widget
  • Facebook Like
  • Google Plus One

Jump to section

  • Article
  • Info & Metrics
  • PDF

Related Articles

  • No related articles found.
  • PubMed
  • Google Scholar

Cited By...

  • No citing articles found.
  • Google Scholar

More in this TOC Section

  • C-myc Oncogene Numerical Imbalances Analysis in Laryngeal Squamous Cell Carcinoma
  • Association of Interleukin-12A Genotypes With Nasopharyngeal Carcinoma Risk
  • Immunogenicity of Neoantigens in Colorectal Cancer: Potential Influence of Tumor Mutation Burden, Stages, and Metastasis
Show more Experimental Studies

Similar Articles

Anticancer Research

© 2025 Anticancer Research

Powered by HighWire