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Research ArticleExperimental Studies

Tumor-specific Cytotoxicity and Type of Cell Death Induced by Peplomycin in Oral Squamous Cell Carcinoma Cell Lines

YU LIU, HIROSHI SAKAGAMI, OSAMU AMANO, HIROTAKA KIKUCHI, YUKIO NAKAMURA, MARIKO ISHIHARA, YUMIKO KANDA, SHIRO KUNII, WEI ZHANG and GUANGYAN YU
Anticancer Research July 2008, 28 (4B) 2197-2204;
YU LIU
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HIROSHI SAKAGAMI
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  • For correspondence: sakagami@dent.meikai.ac.jp
OSAMU AMANO
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HIROTAKA KIKUCHI
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YUKIO NAKAMURA
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MARIKO ISHIHARA
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YUMIKO KANDA
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SHIRO KUNII
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WEI ZHANG
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GUANGYAN YU
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Abstract

The antitumor antibiotic peplomycin showed higher cytostatic antiproliferative effect on five cultured human oral squamous cell carcinoma (OSCC) cell lines (HSC-2, HSC-3, HSC-4, Ca9-22 and NA), as compared with three human oral normal cells (gingival fibroblast HGF, pulp cell HPC and periodontal ligament fibroblast HPLF). Although the antiproliferative activity of peplomycin declined with increasing cell density, peplomycin showed tumor-specific cytotoxicity at any cell density. The five OSCC cell lines showed considerable differences in sensitivity against peplomycin; the HSC-2 cells were the most sensitive, followed by the NA, HSC-3, Ca9-22 and HSC-4 cells. Peplomycin did not induce internucleosomal DNA fragmentation in any of the five OSCC cell lines, and only slightly modified caspase-3, -8 and -9 activities in the HSC-2, Ca9-22 and NA cell lines. Electron microscopy revealed that peplomycin induced the vacuolation of mitochondria accompanying electron lucent matrices lacking cristae and the enlargement of the endoplasmic reticulum in the HSC-2 cells. These data suggest that the anti-proliferative effect of peplomycin is time-dependent, and therefore prolonged treatment with peplomycin in combination with cytotoxic chemotherapeutic agents may induce greater cytotoxic action.

  • Peplomycin
  • type of cell death
  • oral squamous cell carcinoma

Footnotes

  • Received February 4, 2008.
  • Revision received May 2, 2008.
  • Accepted May 9, 2008.
  • Copyright© 2008 International Institute of Anticancer Research (Dr. John G. Delinassios), All rights reserved
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Anticancer Research: 28 (4B)
Anticancer Research
Vol. 28, Issue 4B
July-August 2008
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Tumor-specific Cytotoxicity and Type of Cell Death Induced by Peplomycin in Oral Squamous Cell Carcinoma Cell Lines
YU LIU, HIROSHI SAKAGAMI, OSAMU AMANO, HIROTAKA KIKUCHI, YUKIO NAKAMURA, MARIKO ISHIHARA, YUMIKO KANDA, SHIRO KUNII, WEI ZHANG, GUANGYAN YU
Anticancer Research Jul 2008, 28 (4B) 2197-2204;

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Tumor-specific Cytotoxicity and Type of Cell Death Induced by Peplomycin in Oral Squamous Cell Carcinoma Cell Lines
YU LIU, HIROSHI SAKAGAMI, OSAMU AMANO, HIROTAKA KIKUCHI, YUKIO NAKAMURA, MARIKO ISHIHARA, YUMIKO KANDA, SHIRO KUNII, WEI ZHANG, GUANGYAN YU
Anticancer Research Jul 2008, 28 (4B) 2197-2204;
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