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Research ArticleExperimental Studies

Aberrant Methylation of p16, DLEC1, BLU and E-Cadherin Gene Promoters in Nasopharyngeal Carcinoma Biopsies from Tunisian Patients

WAJDI AYADI, HÉLA KARRAY-HAKIM, ABDELMAJID KHABIR, LAMIA FEKI, SLIM CHARFI, TAHIA BOUDAWARA, ABDELMONEM GHORBEL, JAMEL DAOUD, MOUNIR FRIKHA, PIERRE BUSSON and ADNANE HAMMAMI
Anticancer Research July 2008, 28 (4B) 2161-2167;
WAJDI AYADI
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  • For correspondence: zaidounemail@yahoo.fr
HÉLA KARRAY-HAKIM
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ABDELMAJID KHABIR
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LAMIA FEKI
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SLIM CHARFI
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TAHIA BOUDAWARA
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ABDELMONEM GHORBEL
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JAMEL DAOUD
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MOUNIR FRIKHA
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PIERRE BUSSON
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ADNANE HAMMAMI
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Abstract

Background: Aberrant methylation of tumor suppressor gene (TSG) promoters has been extensively investigated in nasopharyngeal carcinomas (NPC) from South East Asia but not from North Africa. Patients and Methods: The methylation status of p16, deleted in lung and esophageal cancer (DLEC1), zinc finger, MYND-type containing 10 (BLU) and E-cadherin gene promoters was investigated in 44 Tunisian NPC biopsies and three NPC xenografts, by methylation-specific PCR (MSP) combined with a quantitative assessment of some of the samples. Results: The frequencies of aberrant promoter methylation were similar to previous figures reported for Asian series: p16 27/44 (65%), DLEC1 38/44 (86.3%), BLU 15/44 (34.1%) and E-cadherin 35/44 (79.5%). Although in other malignancies, aberrant promoter hypermethylation increases with patient age, it was at the same high frequency in the juvenile and adult forms of Tunisian NPCs. However, there was a strong association between aberrant methylation of E-cadherin promoter and lymph node invasion (p<0.01). In addition, aberrant methylation of the BLU promoter was significantly correlated with an undifferentiated histological type (p=0.03). Conclusion: Aberrant methylation of tumor suppressor genes occurs with the same high frequency in NPCs from North Africa as in South East Asia, regardless of patient age.

  • NPC
  • methylation
  • p16
  • DLEC1
  • BLU
  • E-cadherin

Footnotes

  • Received March 31, 2008.
  • Revision received May 22, 2008.
  • Accepted May 27, 2008.
  • Copyright© 2008 International Institute of Anticancer Research (Dr. John G. Delinassios), All rights reserved
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Anticancer Research: 28 (4B)
Anticancer Research
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July-August 2008
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Aberrant Methylation of p16, DLEC1, BLU and E-Cadherin Gene Promoters in Nasopharyngeal Carcinoma Biopsies from Tunisian Patients
WAJDI AYADI, HÉLA KARRAY-HAKIM, ABDELMAJID KHABIR, LAMIA FEKI, SLIM CHARFI, TAHIA BOUDAWARA, ABDELMONEM GHORBEL, JAMEL DAOUD, MOUNIR FRIKHA, PIERRE BUSSON, ADNANE HAMMAMI
Anticancer Research Jul 2008, 28 (4B) 2161-2167;

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Aberrant Methylation of p16, DLEC1, BLU and E-Cadherin Gene Promoters in Nasopharyngeal Carcinoma Biopsies from Tunisian Patients
WAJDI AYADI, HÉLA KARRAY-HAKIM, ABDELMAJID KHABIR, LAMIA FEKI, SLIM CHARFI, TAHIA BOUDAWARA, ABDELMONEM GHORBEL, JAMEL DAOUD, MOUNIR FRIKHA, PIERRE BUSSON, ADNANE HAMMAMI
Anticancer Research Jul 2008, 28 (4B) 2161-2167;
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