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Research ArticleExperimental Studies

Restoration of FGF Receptor Type 2 Enhances Radiosensitivity of Hormone-refractory Human Prostate Carcinoma PC-3 Cells

AKIO MATSUBARA, JUN TEISHIMA, SUICHINOV MIRKHAT, HIROAKI YASUMOTO, HIDEKI MOCHIZUKI, MITSUHIRO SEKI, KAZUAKI MUTAGUCHI, WALLACE L. MCKEEHAN and TSUGURU USUI
Anticancer Research July 2008, 28 (4B) 2141-2146;
AKIO MATSUBARA
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  • For correspondence: matsua@hiroshima-u.ac.jp
JUN TEISHIMA
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SUICHINOV MIRKHAT
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HIROAKI YASUMOTO
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HIDEKI MOCHIZUKI
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MITSUHIRO SEKI
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KAZUAKI MUTAGUCHI
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WALLACE L. MCKEEHAN
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TSUGURU USUI
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Abstract

Background: This study was undertaken to investigate the radiosensitizing effects of fibroblast growth factor receptor 2IIIb (FGFR2IIIb) in androgen-independent human prostate carcinoma PC-3 cells devoid of normally resident epithelial cell FGFR2IIIb. Materials and Methods: A clonal line of PC-3 cells expressing FGFR2IIIb was established by stable transfection. Clonogenic cell survival, apoptosis and cell cycle distribution with and without gamma-irradiation were then compared between FGFR2IIIb-expressing PC-3 cells and control cells mock-transfected with vector alone. Results: Gamma-irradiation resulted in an increase of clonogenic cell death concurrent with enhanced apoptosis and cell cycle arrest in the G2/M-phase in both transfected and untransfected cells. A quantitative analysis of all three parameters indicated that cells expressing FGFR2IIIb were significantly more sensitive to irradiation than control cells. Conclusion: These results indicate that restoration of FGFR2IIIb to PC-3 cells enhances their sensitivity to irradiation through acceleration of apoptosis and cell cycle arrest.

  • Cell death therapy
  • differentiation therapy
  • gene therapy
  • prostate cancer
  • radiosensitivity
  • tumor suppression
  • tyrosine kinases

Footnotes

  • Received February 22, 2008.
  • Revision received May 19, 2008.
  • Accepted May 21, 2008.
  • Copyright© 2008 International Institute of Anticancer Research (Dr. John G. Delinassios), All rights reserved
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Anticancer Research: 28 (4B)
Anticancer Research
Vol. 28, Issue 4B
July-August 2008
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Restoration of FGF Receptor Type 2 Enhances Radiosensitivity of Hormone-refractory Human Prostate Carcinoma PC-3 Cells
AKIO MATSUBARA, JUN TEISHIMA, SUICHINOV MIRKHAT, HIROAKI YASUMOTO, HIDEKI MOCHIZUKI, MITSUHIRO SEKI, KAZUAKI MUTAGUCHI, WALLACE L. MCKEEHAN, TSUGURU USUI
Anticancer Research Jul 2008, 28 (4B) 2141-2146;

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Restoration of FGF Receptor Type 2 Enhances Radiosensitivity of Hormone-refractory Human Prostate Carcinoma PC-3 Cells
AKIO MATSUBARA, JUN TEISHIMA, SUICHINOV MIRKHAT, HIROAKI YASUMOTO, HIDEKI MOCHIZUKI, MITSUHIRO SEKI, KAZUAKI MUTAGUCHI, WALLACE L. MCKEEHAN, TSUGURU USUI
Anticancer Research Jul 2008, 28 (4B) 2141-2146;
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