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Research ArticleExperimental Studies

HOXB2, an Adverse Prognostic Indicator for Stage I Lung Adenocarcinomas, Promotes Invasion by Transcriptional Regulation of Metastasis-related Genes in HOP-62 Non-small Cell Lung Cancer Cells

KENTARO INAMURA, YUKI TOGASHI, HIRONORI NINOMIYA, TAKASHI SHIMOJI, TETSUO NODA and YUICHI ISHIKAWA
Anticancer Research July 2008, 28 (4B) 2121-2127;
KENTARO INAMURA
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YUKI TOGASHI
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HIRONORI NINOMIYA
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TAKASHI SHIMOJI
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TETSUO NODA
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YUICHI ISHIKAWA
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  • For correspondence: ishikawa@jfcr.or.jp
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Abstract

Background: Previously, using microarray and real-time RT-PCR analysis, we established that HOXB2 is an adverse prognostic indicator for Stage I lung adenocarcinomas. HOXB2 is one of the homeobox master development-controlling genes regulating morphogenesis and cell differentiation. Materials and Methods: The molecular functions of HOXB2 were analyzed with a small interfering RNA (siRNA) approach in HOP-62 human non-small cell lung cancer (NSCLC) cells featuring high HOXB2 expression. Matrigel invasion assays and microarray gene expression analysis were compared between the HOXB2-siRNA cells and the control cells. Results: The Matrigel invasion assays showed attenuation of HOXB2 expression by siRNA to result in a significant decrease of invasiveness compared to the control cells (p=0.0013, paired t-test). On microarray gene expression analysis, up-regulation of many metastasis-related genes and others correlating with HOXB2 expression was observed in the control case. With attenuation of HOXB2 expression, down-regulation was noted for laminins alpha 4 and 5, involved in enriched signaling, and for Mac-2BP (Mac-2 binding protein) and integrin beta 4 amongst the genes having an enriched glycoprotein ontology. Conclusion: HOXB2 promotes invasion of lung cancer cells through the regulation of metastasis-related genes.

  • Lung cancer
  • HOXB2
  • invasion assay
  • microarray
  • gene expression analysis

Footnotes

  • Received March 3, 2008.
  • Revision received May 19, 2008.
  • Accepted May 21, 2008.
  • Copyright© 2008 International Institute of Anticancer Research (Dr. John G. Delinassios), All rights reserved
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Anticancer Research: 28 (4B)
Anticancer Research
Vol. 28, Issue 4B
July-August 2008
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HOXB2, an Adverse Prognostic Indicator for Stage I Lung Adenocarcinomas, Promotes Invasion by Transcriptional Regulation of Metastasis-related Genes in HOP-62 Non-small Cell Lung Cancer Cells
KENTARO INAMURA, YUKI TOGASHI, HIRONORI NINOMIYA, TAKASHI SHIMOJI, TETSUO NODA, YUICHI ISHIKAWA
Anticancer Research Jul 2008, 28 (4B) 2121-2127;

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HOXB2, an Adverse Prognostic Indicator for Stage I Lung Adenocarcinomas, Promotes Invasion by Transcriptional Regulation of Metastasis-related Genes in HOP-62 Non-small Cell Lung Cancer Cells
KENTARO INAMURA, YUKI TOGASHI, HIRONORI NINOMIYA, TAKASHI SHIMOJI, TETSUO NODA, YUICHI ISHIKAWA
Anticancer Research Jul 2008, 28 (4B) 2121-2127;
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