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Research ArticleExperimental Studies

Regulation of Inflammation- and Angiogenesis-related Gene Expression in Breast Cancer Cells and Co-cultured Macrophages

GISELLE T. BURNETT, DENISE C. WEATHERSBY, TIFFANY E. TAYLOR and THEODORE A. BREMNER
Anticancer Research July 2008, 28 (4B) 2093-2099;
GISELLE T. BURNETT
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DENISE C. WEATHERSBY
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TIFFANY E. TAYLOR
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THEODORE A. BREMNER
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  • For correspondence: tbremner@howard.edu
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Abstract

Background: Tumor-associated macrophages (TAMs) secrete key modifiers of tumor progression and their modification has been proposed as a therapeutic strategy. Phenotypic changes that may render TAMs selectively vulnerable to anti-cancer agents were examined. Materials and Methods: Gene arrays, reverse transcription-polymerase chain reaction and Western blotting were used to study inflammation- and angiogenesis-related gene expression in co-cultured breast cancer cells and macrophages and to determine how their interactions were affected by tamoxifen and aspirin. Results: MCF-7 (mammary adenocarcinoma) cells down-regulated macrophage migration inhibitory factor (MIF), but tamoxifen-pretreated MCF-7 cells up-regulated MIF in co-cultured macrophages. Two molecular variants of MIF were observed in the co-cultured MCF-7 cells. Aspirin induced IL-10 expression in the macrophages, MCF-7 and tamoxifen-pretreated MCF-7 cells. Aspirin-pretreated macrophages potently induced IL-10 expression in the MCF-7 cells. Conclusion: Because MIF is a determinant of the M1 macrophage activation state, the MCF-7-induced ablation of MIF in TAMs is suggestive of partial M2 polarization. Tamoxifen modulates MCF-7 regulation of TAM gene expression and aspirin alters macrophage regulation of MCF-7 gene expression.

  • Angiogenesis
  • inflammation
  • MIF
  • IL-10
  • tamoxifen
  • aspirin

Footnotes

  • Received January 28, 2008.
  • Revision received May 5, 2008.
  • Accepted May 9, 2008.
  • Copyright© 2008 International Institute of Anticancer Research (Dr. John G. Delinassios), All rights reserved
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Anticancer Research: 28 (4B)
Anticancer Research
Vol. 28, Issue 4B
July-August 2008
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Regulation of Inflammation- and Angiogenesis-related Gene Expression in Breast Cancer Cells and Co-cultured Macrophages
GISELLE T. BURNETT, DENISE C. WEATHERSBY, TIFFANY E. TAYLOR, THEODORE A. BREMNER
Anticancer Research Jul 2008, 28 (4B) 2093-2099;

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Regulation of Inflammation- and Angiogenesis-related Gene Expression in Breast Cancer Cells and Co-cultured Macrophages
GISELLE T. BURNETT, DENISE C. WEATHERSBY, TIFFANY E. TAYLOR, THEODORE A. BREMNER
Anticancer Research Jul 2008, 28 (4B) 2093-2099;
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