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Research ArticleExperimental Studies

EMMPRIN Modulates Migration and Deposition of TN-C in Oral Squamous Carcinoma

DONGMIN DANG, AMHA ATAKILIT and DANIEL M. RAMOS
Anticancer Research July 2008, 28 (4B) 2049-2054;
DONGMIN DANG
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AMHA ATAKILIT
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DANIEL M. RAMOS
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  • For correspondence: Daniel.ramos@ucsf.edu
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Abstract

The extracellular matrix metalloproteinase inducer (EMMPRIN), found on the surface of many tumor cells, stimulates the production of matrix metalloproteinases (MMPs) by both fibroblasts and the tumor cells themselves. To evaluate its possible role as a tumor promoter, we first overexpressed EMMPRIN, by retroviral transduction, into poorly invasive squamous cell carcinoma (SCC) cells. Secondly, we knocked down its expression using small interfering RNA (siRNA) in invasive SCC cells. The cell lines were then re-evaluated for migration on fibronectin (FN). Overexpression of EMMPRIN, promoted motility, whereas the siRNA decreased migration. The MMP expression by these variant SCC cell lines was also manipulated by EMMPRIN. The expression of MMP-2, -3, and -9 coincided with the expression of EMMPRIN. Cocultures of SCC/peritumor fibroblasts (PTF) were used to investigate tenascin-C (TN-C) matrix deposition. The cocultures overexpressing EMMPRIN, deposited several fold greater levels of TN-C compared to the control cocultures. In addition, the siRNA cocultures deposited minimal amounts of TN-C. In the presence of the broad spectrum MMP inhibitor, GM6001, TN-C deposition by the EMMPRIN overexpressing cocultures was suppressed. Thus EMMPRIN regulates migration, MMP production by SCC cells and deposition of the TN-C matrix.

  • EMMPRIN
  • invasion
  • oral SCC
  • TN-C
  • MMP

Footnotes

  • Received February 6, 2008.
  • Revision received May 7, 2008.
  • Accepted May 14, 2008.
  • Copyright© 2008 International Institute of Anticancer Research (Dr. John G. Delinassios), All rights reserved
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Anticancer Research: 28 (4B)
Anticancer Research
Vol. 28, Issue 4B
July-August 2008
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EMMPRIN Modulates Migration and Deposition of TN-C in Oral Squamous Carcinoma
DONGMIN DANG, AMHA ATAKILIT, DANIEL M. RAMOS
Anticancer Research Jul 2008, 28 (4B) 2049-2054;

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EMMPRIN Modulates Migration and Deposition of TN-C in Oral Squamous Carcinoma
DONGMIN DANG, AMHA ATAKILIT, DANIEL M. RAMOS
Anticancer Research Jul 2008, 28 (4B) 2049-2054;
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