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Research ArticleExperimental Studies

Long-term Postoperative Adjuvant Chemotherapy of UFT/LV Improves Survival in a Primary Tumor Resection-Pulmonary Metastasis Model

SOTARO SADAHIRO, TOSHIYUKI SUZUKI, YUJI MAEDA, AKIRA TANAKA, HIROYASU MAKUUCHI, AKEMI KAMIJO and CHIEKO MURAYAMA
Anticancer Research July 2008, 28 (4B) 2045-2048;
SOTARO SADAHIRO
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  • For correspondence: sadahiro@is.icc.u-tokai.ac.jp
TOSHIYUKI SUZUKI
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YUJI MAEDA
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AKIRA TANAKA
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HIROYASU MAKUUCHI
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AKEMI KAMIJO
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CHIEKO MURAYAMA
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Abstract

Background: The optimum regimen and optimum duration of administration of postoperative chemotherapy would vary with the postoperative residual tumor volume. Whether or not prolonged administration of oral uracil/tegafur (UFT) with leucovorin (LV) would prolong the survival period was assessed experimentally. Materials and Methods: Murine models of pulmonary metastasis with different volumes of residual tumor after primary tumor resection were prepared, and the efficacy of 12-week and 4-week oral administration of UFT/LV as postoperative adjuvant chemotherapy was compared. Results: In the model with only a small volume of occult residual tumor after early resection of the primary tumor, the survival period in the 12-week UFT/LV group was significantly increased as compared with that in the untreated group, whereas no significant difference was noted between the 4-week UFT/LV group and the untreated group. Conclusion: Long-term administration of UFT/LV as postoperative adjuvant chemotherapy may be potentially beneficial.

  • UFT
  • LV
  • adjuvant chemotherapy
  • micrometastasis

Footnotes

  • Received April 17, 2008.
  • Revision received June 13, 2008.
  • Accepted June 25, 2008.
  • Copyright© 2008 International Institute of Anticancer Research (Dr. John G. Delinassios), All rights reserved
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Anticancer Research: 28 (4B)
Anticancer Research
Vol. 28, Issue 4B
July-August 2008
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Long-term Postoperative Adjuvant Chemotherapy of UFT/LV Improves Survival in a Primary Tumor Resection-Pulmonary Metastasis Model
SOTARO SADAHIRO, TOSHIYUKI SUZUKI, YUJI MAEDA, AKIRA TANAKA, HIROYASU MAKUUCHI, AKEMI KAMIJO, CHIEKO MURAYAMA
Anticancer Research Jul 2008, 28 (4B) 2045-2048;

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Long-term Postoperative Adjuvant Chemotherapy of UFT/LV Improves Survival in a Primary Tumor Resection-Pulmonary Metastasis Model
SOTARO SADAHIRO, TOSHIYUKI SUZUKI, YUJI MAEDA, AKIRA TANAKA, HIROYASU MAKUUCHI, AKEMI KAMIJO, CHIEKO MURAYAMA
Anticancer Research Jul 2008, 28 (4B) 2045-2048;
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