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Research ArticleExperimental Studies

Subcellular Colocalization of Hypericin with Respect to Endoplasmic Reticulum and Golgi Apparatus in Glioblastoma Cells

RAINER RITZ, FLORIAN ROSER, NORBERT RADOMSKI, WOLFGANG S.L. STRAUSS, MARCOS TATAGIBA and ALIREZA GHARABAGHI
Anticancer Research July 2008, 28 (4B) 2033-2038;
RAINER RITZ
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  • For correspondence: rainer.ritz@med.uni-tuebingen.de
FLORIAN ROSER
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NORBERT RADOMSKI
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WOLFGANG S.L. STRAUSS
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MARCOS TATAGIBA
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ALIREZA GHARABAGHI
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Abstract

Background: To improve the poor prognosis of patients suffering from malignant glioma, hypericin (HYP)-based photodynamic therapy might be a promising approach. Intracellular localization of HYP was investigated by quantitative colocalization analysis with respect to endoplasmic reticulum (ER) and Golgi apparatus (GA) by double staining experiments with fluorescence microscopy. Materials and Methods: U373 MG glioblastoma cells were stained with HYP and costainings were applied for specific organelle markers for ER and GA. Results: In cells double-stained with HYP and ER-Tracker, 57% of HYP signals were found within the ER and 52% of the ER compartment showed HYP signals. The colocalization fraction of HYP found in the GA was 36% and 46% of the GA showed HYP signals. Conclusion: In glioblastoma cells, a considerable fraction of HYP is localized in the ER; in addition, a significant amount of the photosensitizer shows colocalization with the GA.

  • Hypericin
  • photodynamic therapy
  • glioma
  • intracellular localization
  • endoplasmatic reticulum
  • Golgi apparatus

Footnotes

  • Received February 20, 2008.
  • Revision received May 14, 2008.
  • Accepted May 15, 2008.
  • Copyright© 2008 International Institute of Anticancer Research (Dr. John G. Delinassios), All rights reserved
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Anticancer Research: 28 (4B)
Anticancer Research
Vol. 28, Issue 4B
July-August 2008
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Subcellular Colocalization of Hypericin with Respect to Endoplasmic Reticulum and Golgi Apparatus in Glioblastoma Cells
RAINER RITZ, FLORIAN ROSER, NORBERT RADOMSKI, WOLFGANG S.L. STRAUSS, MARCOS TATAGIBA, ALIREZA GHARABAGHI
Anticancer Research Jul 2008, 28 (4B) 2033-2038;

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Subcellular Colocalization of Hypericin with Respect to Endoplasmic Reticulum and Golgi Apparatus in Glioblastoma Cells
RAINER RITZ, FLORIAN ROSER, NORBERT RADOMSKI, WOLFGANG S.L. STRAUSS, MARCOS TATAGIBA, ALIREZA GHARABAGHI
Anticancer Research Jul 2008, 28 (4B) 2033-2038;
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