Skip to main content

Main menu

  • Home
  • Current Issue
  • Archive
  • Info for
    • Authors
    • Editorial Policies
    • Subscribers
    • Advertisers
    • Editorial Board
    • Special Issues 2025
  • Journal Metrics
  • Other Publications
    • In Vivo
    • Cancer Genomics & Proteomics
    • Cancer Diagnosis & Prognosis
  • More
    • IIAR
    • Conferences
    • 2008 Nobel Laureates
  • About Us
    • General Policy
    • Contact
  • Other Publications
    • Anticancer Research
    • In Vivo
    • Cancer Genomics & Proteomics

User menu

  • Register
  • Subscribe
  • My alerts
  • Log in
  • My Cart

Search

  • Advanced search
Anticancer Research
  • Other Publications
    • Anticancer Research
    • In Vivo
    • Cancer Genomics & Proteomics
  • Register
  • Subscribe
  • My alerts
  • Log in
  • My Cart
Anticancer Research

Advanced Search

  • Home
  • Current Issue
  • Archive
  • Info for
    • Authors
    • Editorial Policies
    • Subscribers
    • Advertisers
    • Editorial Board
    • Special Issues 2025
  • Journal Metrics
  • Other Publications
    • In Vivo
    • Cancer Genomics & Proteomics
    • Cancer Diagnosis & Prognosis
  • More
    • IIAR
    • Conferences
    • 2008 Nobel Laureates
  • About Us
    • General Policy
    • Contact
  • Visit us on Facebook
  • Follow us on Linkedin
Research ArticleExperimental Studies

Apoptosis Regulation and Spontaneous Apoptosis Index of Testicular Germ Cell Tumors are Associated with Differentiation and Resistance to Systemic Treatment

LÁSZLÓ MÁNDOKY, BÉLA SZENDE, LAJOS GÉCZI, ISTVÁN BODROGI, MIKLÓS KÁSLER and MIHÁLY BAK
Anticancer Research May 2008, 28 (3A) 1641-1649;
LÁSZLÓ MÁNDOKY
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
BÉLA SZENDE
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
LAJOS GÉCZI
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
ISTVÁN BODROGI
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
MIKLÓS KÁSLER
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
MIHÁLY BAK
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • For correspondence: bak@oncol.hu
  • Article
  • Info & Metrics
  • PDF
Loading

Abstract

Background: Cisplatin-based chemotherapy can cure more than 80% of metastatic germ cell testicular tumors (GCT). Germ cells are particularly susceptible to apoptosis and it is reasonable to presume that GCTs are curable because of an intact and effective apoptotic pathway. Patients and Methods: The expression of p53 and p21 was investigated in conjunction with the spontaneous apoptotic index in 20 refractory and 50 chemosensitive GCTs, with a complete follow-up. To detect a differentiation-dependent alteration in the apoptotic pathway, all of the histological tumor types were examined separately. Results: Embryonal carcinoma components showed significantly higher p53 expression compared to other histological subtypes of GCTs. p21 was barely detectable in the majority of tumors. Seminomatous components showed no p21 expression. Mature teratomas and syncytiotrophoblasts showed significantly higher p21 expression than other tumor subtypes. Embryonal carcinomas showed significantly higher apoptotic indices than other non-seminomatous components. On the other hand, choriocarcinomas and mature teratomas showed the lowest spontaneous apoptotic potential. The apoptotic index correlated with the fraction of p53-positive cells, but not with the p21 expression rate. The refractory group showed significantly lower p53 expression, higher p21 expression and a higher apoptosis index than the sensitive group. Conclusion: Our results suggest that the p53 and p21 expression levels and the apoptosis index seem to be important factors in the issue of the chemosensitivity of GCTs. The protein expression pattern reflects a differentiation-dependent preference for G1/S-phase arrest in terminally differentiated syncytiotrophoblasts and mature teratoma cells, while p53 mediated apoptosis induction is meaning to less differentiated tumor types.

  • Germ-cell testicular tumor
  • differentiation
  • chemoresistance
  • apoptosis
  • p53
  • p21

Footnotes

  • Received December 18, 2007.
  • Revision received March 31, 2008.
  • Accepted April 1, 2008.
  • Copyright© 2008 International Institute of Anticancer Research (Dr. John G. Delinassios), All rights reserved
PreviousNext
Back to top

In this issue

Anticancer Research: 28 (3A)
Anticancer Research
Vol. 28, Issue 3A
May-June 2008
  • Table of Contents
  • Table of Contents (PDF)
  • Index by author
  • Front Matter (PDF)
Download PDF
Article Alerts
Sign In to Email Alerts with your Email Address
Email Article

Thank you for your interest in spreading the word on Anticancer Research.

NOTE: We only request your email address so that the person you are recommending the page to knows that you wanted them to see it, and that it is not junk mail. We do not capture any email address.

Enter multiple addresses on separate lines or separate them with commas.
Apoptosis Regulation and Spontaneous Apoptosis Index of Testicular Germ Cell Tumors are Associated with Differentiation and Resistance to Systemic Treatment
(Your Name) has sent you a message from Anticancer Research
(Your Name) thought you would like to see the Anticancer Research web site.
CAPTCHA
This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.
5 + 0 =
Solve this simple math problem and enter the result. E.g. for 1+3, enter 4.
Citation Tools
Apoptosis Regulation and Spontaneous Apoptosis Index of Testicular Germ Cell Tumors are Associated with Differentiation and Resistance to Systemic Treatment
LÁSZLÓ MÁNDOKY, BÉLA SZENDE, LAJOS GÉCZI, ISTVÁN BODROGI, MIKLÓS KÁSLER, MIHÁLY BAK
Anticancer Research May 2008, 28 (3A) 1641-1649;

Citation Manager Formats

  • BibTeX
  • Bookends
  • EasyBib
  • EndNote (tagged)
  • EndNote 8 (xml)
  • Medlars
  • Mendeley
  • Papers
  • RefWorks Tagged
  • Ref Manager
  • RIS
  • Zotero
Reprints and Permissions
Share
Apoptosis Regulation and Spontaneous Apoptosis Index of Testicular Germ Cell Tumors are Associated with Differentiation and Resistance to Systemic Treatment
LÁSZLÓ MÁNDOKY, BÉLA SZENDE, LAJOS GÉCZI, ISTVÁN BODROGI, MIKLÓS KÁSLER, MIHÁLY BAK
Anticancer Research May 2008, 28 (3A) 1641-1649;
Twitter logo Facebook logo Mendeley logo
  • Tweet Widget
  • Facebook Like
  • Google Plus One

Jump to section

  • Article
  • Info & Metrics
  • PDF

Related Articles

  • No related articles found.
  • PubMed
  • Google Scholar

Cited By...

  • No citing articles found.
  • Google Scholar

More in this TOC Section

  • Tissue Prognostic Markers for Clear Cell Renal Cell Carcinoma Tumor-stroma Interaction: Impact on TNM Staging Parameters
  • CA9-Positive Keloid Fibroblasts: Modulator of Local Inflammation Induced by the Hypoxic and Glycolysis-enhanced Microenvironment
  • Predictive Factors for Multiple Metastases of Clear-cell Renal Cell Carcinoma
Show more Experimental Studies

Similar Articles

Anticancer Research

© 2025 Anticancer Research

Powered by HighWire