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Research ArticleExperimental Studies

Biphenylalkylacetylhydroquinone Ethers Suppress the Proliferation of Murine B16 Melanoma Cells

NICOLLE FERNANDES, MANFRED JUNG, ALI DAOUD and HUANBIAO MO
Anticancer Research March 2008, 28 (2A) 1005-1012;
NICOLLE FERNANDES
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MANFRED JUNG
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ALI DAOUD
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HUANBIAO MO
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  • For correspondence: hmo@mail.twu.edu
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Abstract

Hydroquinone, an activator of caspase-9 activity via reactive oxygen species, and farnesol, a post-translational down-regulator of 3-hydroxy-3-methylglutaryl coenzyme A reductase activity suppress the growth of murine B16 melanoma cells. Our previous studies have shown that farnesyl-O-acetylhydroquinone has a markedly greater growth-suppressive activity than that predicted by the responses to the parent compounds. Perillyl alcohol, a modulator of small G-protein activity, and biphenyl compounds, activators of Fas-mediated death pathways, suppress B16 growth. A similar synergistic increase in the potency of each compound when ether-linked to acetylhydroquinone is reported. Perillyl-O-acetylhydroquinone, biphenylethyl-O-acetylhydroquinone and biphenylpropyl-O-acetylhydroquinone had dose-dependent impacts on the proliferation of B16 cells with 50% inhibitory concentration (IC50) values of 8.0, 4.2 and 1.4 μmol/L, respectively. The growth-suppression effected by biphenylpropyl-O-acetylhydroquinone was accompanied by a dose-dependent arrest at the G1/S interface of the cell cycle, an impact greater than that previously reported for farnesyl-O-acetylhydroquinone (IC50=2.5 μmol/L). These new hydroquinone derivatives may have potential in cancer chemoprevention and/or therapy.

  • Biphenylalkyl hydroquinone
  • cell cycle arrest
  • B16 melanoma

Footnotes

  • Abbreviations: IC50, the concentration required to suppress the increase in the population of cells by 50%; FBS, fetal bovine serum; HBSS, Hanks'-balanced salt solution; MEM, Eagle's minimum essential medium.

  • Received August 1, 2007.
  • Revision received October 11, 2007.
  • Accepted December 7, 2007.
  • Copyright© 2008 International Institute of Anticaner Research (Dr. John G. Delinassios), All rights reserved
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Anticancer Research: 28 (2A)
Anticancer Research
Vol. 28, Issue 2A
March-April 2008
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Biphenylalkylacetylhydroquinone Ethers Suppress the Proliferation of Murine B16 Melanoma Cells
NICOLLE FERNANDES, MANFRED JUNG, ALI DAOUD, HUANBIAO MO
Anticancer Research Mar 2008, 28 (2A) 1005-1012;

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Biphenylalkylacetylhydroquinone Ethers Suppress the Proliferation of Murine B16 Melanoma Cells
NICOLLE FERNANDES, MANFRED JUNG, ALI DAOUD, HUANBIAO MO
Anticancer Research Mar 2008, 28 (2A) 1005-1012;
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