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Research ArticleExperimental Studies

Polymorphisms of Death Pathway Genes FAS and FASL and Risk of Premalignant Gastric Lesions

PING-I HSU, PEI-JUNG LU, E-MING WANG, LUO-PING GER, GIN-HO LO, FENG-WOEI TSAY, TAI-AN CHEN, HSIAO-BAI YANG, HUI-CHUN CHEN, WEIR-SEN LIN and KWOK-HUNG LAI
Anticancer Research January 2008, 28 (1A) 97-103;
PING-I HSU
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  • For correspondence: williamhsup@yahoo.com.tw
PEI-JUNG LU
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E-MING WANG
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LUO-PING GER
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GIN-HO LO
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FENG-WOEI TSAY
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TAI-AN CHEN
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HSIAO-BAI YANG
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HUI-CHUN CHEN
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WEIR-SEN LIN
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KWOK-HUNG LAI
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Abstract

Background: Tumorigenesis is a multistep process that begins with the abrogation of normal controls of apoptosis and cell proliferation, and the FAS receptor-ligand system is a key regulator of apoptosis. The aim of this study was to investigate whether functional polymorphisms of death pathway genes (FAS and FASL) are associated with the development of gastric atrophy and intestinal metaplasia. Patients and Methods: Genotypes in the promoter regions of the FAS (-1377G/A and -670A/G) and FASL (-844T/C) genes of 101 healthy individuals and 86 gastric cancer patients were determined by PCR-RFLP. Additionally, gastric histological changes were examined according to the updated Sydney System. Results: The carriage of FASL -844C allele significantly increased the risk of atrophy in the gastric corpus, with an adjusted odds ratio (OR) of 5.0 [95% confidence interval (CI), 1.5-6.8]. There were no gene-gene interactions among FASL -844T/C, FAS -1377G/A and FAS -670A/G polymorphisms in developing premalignant gastric lesions. In the 109 individuals with Helicobacter pylori infection, carrying the FAS -1377A allele was a protective factor for developing intestinal metaplasia in the antrum (OR, 0.3; 95% CI, 0.1-0.9), while carrying the FASL -844C allele was a risk factor for developing gastric atrophy in the corpus (OR, 9.4; 95% CI, 1.7-53.4). Conclusion: FAS and FASL genotypes of the hosts are important determinants in the pathogenesis of gastric atrophy and intestinal metaplasia in H. pylori-infected individuals.

  • FAS
  • FASL
  • polymorphism
  • apoptosis
  • atrophy
  • intestinal metaplasia
  • Received August 17, 2007.
  • Revision received December 7, 2007.
  • Accepted December 18, 2007.
  • Copyright© 2008 International Institute of Anticaner Research (Dr. John G. Delinassios), All rights reserved
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Anticancer Research: 28 (1A)
Anticancer Research
Vol. 28, Issue 1A
January-February 2008
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Polymorphisms of Death Pathway Genes FAS and FASL and Risk of Premalignant Gastric Lesions
PING-I HSU, PEI-JUNG LU, E-MING WANG, LUO-PING GER, GIN-HO LO, FENG-WOEI TSAY, TAI-AN CHEN, HSIAO-BAI YANG, HUI-CHUN CHEN, WEIR-SEN LIN, KWOK-HUNG LAI
Anticancer Research Jan 2008, 28 (1A) 97-103;

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Polymorphisms of Death Pathway Genes FAS and FASL and Risk of Premalignant Gastric Lesions
PING-I HSU, PEI-JUNG LU, E-MING WANG, LUO-PING GER, GIN-HO LO, FENG-WOEI TSAY, TAI-AN CHEN, HSIAO-BAI YANG, HUI-CHUN CHEN, WEIR-SEN LIN, KWOK-HUNG LAI
Anticancer Research Jan 2008, 28 (1A) 97-103;
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