Skip to main content

Main menu

  • Home
  • Current Issue
  • Archive
  • Info for
    • Authors
    • Editorial Policies
    • Subscribers
    • Advertisers
    • Editorial Board
    • Special Issues 2025
  • Journal Metrics
  • Other Publications
    • In Vivo
    • Cancer Genomics & Proteomics
    • Cancer Diagnosis & Prognosis
  • More
    • IIAR
    • Conferences
    • 2008 Nobel Laureates
  • About Us
    • General Policy
    • Contact
  • Other Publications
    • Anticancer Research
    • In Vivo
    • Cancer Genomics & Proteomics

User menu

  • Register
  • Subscribe
  • My alerts
  • Log in
  • My Cart

Search

  • Advanced search
Anticancer Research
  • Other Publications
    • Anticancer Research
    • In Vivo
    • Cancer Genomics & Proteomics
  • Register
  • Subscribe
  • My alerts
  • Log in
  • My Cart
Anticancer Research

Advanced Search

  • Home
  • Current Issue
  • Archive
  • Info for
    • Authors
    • Editorial Policies
    • Subscribers
    • Advertisers
    • Editorial Board
    • Special Issues 2025
  • Journal Metrics
  • Other Publications
    • In Vivo
    • Cancer Genomics & Proteomics
    • Cancer Diagnosis & Prognosis
  • More
    • IIAR
    • Conferences
    • 2008 Nobel Laureates
  • About Us
    • General Policy
    • Contact
  • Visit us on Facebook
  • Follow us on Linkedin
Research ArticleExperimental Studies

Delta(9)-tetrahydrocannabinol Inhibits 17β-Estradiol-induced Proliferation and Fails to Activate Androgen and Estrogen Receptors in MCF7 Human Breast Cancer Cells

A. O. VON BUEREN, M. SCHLUMPF and W. LICHTENSTEIGER
Anticancer Research January 2008, 28 (1A) 85-89;
A. O. VON BUEREN
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • For correspondence: Andre.vonBueren@kispi.uzh.ch
M. SCHLUMPF
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
W. LICHTENSTEIGER
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • Article
  • Info & Metrics
  • PDF
Loading

Abstract

Background: Delta(9)-tetrahydrocannabinol (THC) exerts palliative effects in cancer patients, but produces adverse effects on the endocrine and reproductive systems. Experimental evidence concerning such effects is controversial. Whether THC exhibits estrogenic or androgenic activity in vitro was investigated. Materials and Methods: Estrogenic effects of THC were analyzed in vitro by measuring the proliferation of estrogen-sensitive MCF7 cells. Androgenic activity was investigated by the A-Screen assay that measures androgen-dependent inhibition of proliferation of the androgen receptor (AR)-positive human mammary carcinoma cell line, MCF7-AR1. Results: In contrast to 17β-estradiol, included as positive control with an EC50 value (concentration required for 50% of maximal 17β-estradiol-induced proliferation) of 1.00×10-12 M, THC failed to induce cell proliferation in the MCF7 cell line at concentrations between 10-13 and 10-4 M. THC inhibited 17β-estradiol-induced proliferation in wild-type MCF7 and MCF7-AR1 cells, with an IC50 value of 2.6×10-5 M and 9×10-6 M, respectively. Conclusion: THC failed to act as an estrogen, but antagonized 17β-estradiol-induced proliferation. This effect was independent of the AR expression level.

  • Cannabinoids
  • breast cancer
  • androgen receptor
  • estrogen receptor
  • Received October 3, 2007.
  • Revision received November 9, 2007.
  • Accepted November 28, 2007.
  • Copyright© 2008 International Institute of Anticaner Research (Dr. John G. Delinassios), All rights reserved
PreviousNext
Back to top

In this issue

Anticancer Research: 28 (1A)
Anticancer Research
Vol. 28, Issue 1A
January-February 2008
  • Table of Contents
  • Table of Contents (PDF)
  • Index by author
  • Ed Board (PDF)
  • Front Matter (PDF)
Download PDF
Article Alerts
Sign In to Email Alerts with your Email Address
Email Article

Thank you for your interest in spreading the word on Anticancer Research.

NOTE: We only request your email address so that the person you are recommending the page to knows that you wanted them to see it, and that it is not junk mail. We do not capture any email address.

Enter multiple addresses on separate lines or separate them with commas.
Delta(9)-tetrahydrocannabinol Inhibits 17β-Estradiol-induced Proliferation and Fails to Activate Androgen and Estrogen Receptors in MCF7 Human Breast Cancer Cells
(Your Name) has sent you a message from Anticancer Research
(Your Name) thought you would like to see the Anticancer Research web site.
CAPTCHA
This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.
12 + 3 =
Solve this simple math problem and enter the result. E.g. for 1+3, enter 4.
Citation Tools
Delta(9)-tetrahydrocannabinol Inhibits 17β-Estradiol-induced Proliferation and Fails to Activate Androgen and Estrogen Receptors in MCF7 Human Breast Cancer Cells
A. O. VON BUEREN, M. SCHLUMPF, W. LICHTENSTEIGER
Anticancer Research Jan 2008, 28 (1A) 85-89;

Citation Manager Formats

  • BibTeX
  • Bookends
  • EasyBib
  • EndNote (tagged)
  • EndNote 8 (xml)
  • Medlars
  • Mendeley
  • Papers
  • RefWorks Tagged
  • Ref Manager
  • RIS
  • Zotero
Reprints and Permissions
Share
Delta(9)-tetrahydrocannabinol Inhibits 17β-Estradiol-induced Proliferation and Fails to Activate Androgen and Estrogen Receptors in MCF7 Human Breast Cancer Cells
A. O. VON BUEREN, M. SCHLUMPF, W. LICHTENSTEIGER
Anticancer Research Jan 2008, 28 (1A) 85-89;
Twitter logo Facebook logo Mendeley logo
  • Tweet Widget
  • Facebook Like
  • Google Plus One

Jump to section

  • Article
  • Info & Metrics
  • PDF

Related Articles

  • No related articles found.
  • PubMed
  • Google Scholar

Cited By...

  • Histone Modifications Are Associated with {Delta}9-Tetrahydrocannabinol-mediated Alterations in Antigen-specific T Cell Responses
  • Google Scholar

More in this TOC Section

  • Predictive Factors for Multiple Metastases of Clear-cell Renal Cell Carcinoma
  • Acyclic Retinoid Overcomes Vemurafenib Resistance in Melanoma Cells via Dual Inhibition of MAPK and PI3K/AKT/mTOR Pathways
  • Tumor Immunology Visualized in Realtime in In-vivo-like 3-D Gelfoam® Histoculture by Color-coded Imaging
Show more Experimental Studies

Similar Articles

Anticancer Research

© 2025 Anticancer Research

Powered by HighWire