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Research ArticleExperimental Studies

Adenovirus Vector-mediated Gene Therapy Using Iodized Oil Esters for Hepatocellular Carcinoma in Rats

HIROAKI SHIBA, TAKEYUKI MISAWA, TOMONORI IIDA, TOMOYOSHI OKAMOTO, YASURO FUTAGAWA, MINORI SAKURAI, TOYA OHASHI, YOSHIKATSU ETO and KATSUHIKO YANAGA
Anticancer Research January 2008, 28 (1A) 51-53;
HIROAKI SHIBA
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  • For correspondence: hs0817@jikei.ac.jp
TAKEYUKI MISAWA
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TOMONORI IIDA
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TOMOYOSHI OKAMOTO
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YASURO FUTAGAWA
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MINORI SAKURAI
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TOYA OHASHI
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YOSHIKATSU ETO
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KATSUHIKO YANAGA
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Abstract

Background: When gene therapy is performed for malignant tumors, gene transfer efficiency and selectivity are extremely important. The usefulness of gene therapy by intra-arterial injection of an adenovirus vector with iodized oil esters (IOEs) for hepatocellular carcinoma (HCC) was studied. Materials and Methods: HCC was induced in rats with diethyl nitrosamine and phenobarbital, after which either adenovirus vector expressing the herpes simplex virus thymidine kinase (AxCAHSVtk) and IOEs or AxCAHSVtk alone was injected through the hepatic artery. On postoperative days 2, 4 and 6, gancyclovir was injected into the peritoneum; blood sampling was performed on day 7. Results: Aspartate aminotransferase and alanine aminotransferase levels in the AxCAHSVtk with IOEs group were lower than in the AxCAHSVtk alone group (p=0.0274, p=0.0323). However, the survival rate was not significantly different between groups (p=0.7122). Conclusion: Intra-arterial injection of an adenovirus vector with IOEs can result in cancer-selective but not effective gene therapy for HCC.

  • Gene therapy
  • hepatocellular carcinoma
  • adenovirus vector
  • arterial injection
  • iodized oil
  • rat
  • Received October 2, 2007.
  • Revision received December 6, 2007.
  • Accepted December 14, 2007.
  • Copyright© 2008 International Institute of Anticaner Research (Dr. John G. Delinassios), All rights reserved
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Anticancer Research: 28 (1A)
Anticancer Research
Vol. 28, Issue 1A
January-February 2008
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Adenovirus Vector-mediated Gene Therapy Using Iodized Oil Esters for Hepatocellular Carcinoma in Rats
HIROAKI SHIBA, TAKEYUKI MISAWA, TOMONORI IIDA, TOMOYOSHI OKAMOTO, YASURO FUTAGAWA, MINORI SAKURAI, TOYA OHASHI, YOSHIKATSU ETO, KATSUHIKO YANAGA
Anticancer Research Jan 2008, 28 (1A) 51-53;

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Adenovirus Vector-mediated Gene Therapy Using Iodized Oil Esters for Hepatocellular Carcinoma in Rats
HIROAKI SHIBA, TAKEYUKI MISAWA, TOMONORI IIDA, TOMOYOSHI OKAMOTO, YASURO FUTAGAWA, MINORI SAKURAI, TOYA OHASHI, YOSHIKATSU ETO, KATSUHIKO YANAGA
Anticancer Research Jan 2008, 28 (1A) 51-53;
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