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Research ArticleExperimental Studies

Valproate Protective Effects on Cisplatin-induced Peripheral Neuropathy: An In Vitro and In Vivo Study

VIRGINIA RODRIGUEZ-MENENDEZ, ALESSANDRA GILARDINI, MARIO BOSSI, ANNALISA CANTA, NORBERTO OGGIONI, VALENTINA CAROZZI, LUCIO TREMOLIZZO and GUIDO CAVALETTI
Anticancer Research January 2008, 28 (1A) 335-342;
VIRGINIA RODRIGUEZ-MENENDEZ
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ALESSANDRA GILARDINI
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MARIO BOSSI
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ANNALISA CANTA
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NORBERTO OGGIONI
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VALENTINA CAROZZI
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LUCIO TREMOLIZZO
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GUIDO CAVALETTI
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  • For correspondence: guido.cavaletti@unimib.it
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Abstract

Background: Antineoplastic drugs, such as cisplatin (CDDP), induce disabling peripheral neuropathies, representing a hindrance to effective cancer treatments. The exact pathogenesis of CDDP-induced neuropathy is not yet understood, and the dysregulation of gene expression has been proposed. Valproate (VPA) is an antiepileptic drug recently discovered to remodel gene expression, with hypothetically putative neuroprotective effects. Materials and Methods: VPA was tested in both, in vitro and in vivo models of CDDP-neurotoxicity. Results: VPA administered in combination with CDDP promoted dorsal root ganglia (DRG) neurons survival. Moreover, this treatment induced in Wistar rats an improvement of body weight, sensory nerve conduction velocity, and DRG morphometric analysis. In contrast, VPA was not able to rescue CDDP pre-treated rats. Conclusion: When used in combination with CDDP, VPA displays a protective action against neuropathy, in our models, suggesting possible future clinical applications.

  • Cisplatin
  • neuropathy
  • valproate
  • neuroprotection
  • Received September 11, 2007.
  • Revision received November 21, 2007.
  • Accepted December 11, 2007.
  • Copyright© 2008 International Institute of Anticaner Research (Dr. John G. Delinassios), All rights reserved
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Anticancer Research: 28 (1A)
Anticancer Research
Vol. 28, Issue 1A
January-February 2008
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Valproate Protective Effects on Cisplatin-induced Peripheral Neuropathy: An In Vitro and In Vivo Study
VIRGINIA RODRIGUEZ-MENENDEZ, ALESSANDRA GILARDINI, MARIO BOSSI, ANNALISA CANTA, NORBERTO OGGIONI, VALENTINA CAROZZI, LUCIO TREMOLIZZO, GUIDO CAVALETTI
Anticancer Research Jan 2008, 28 (1A) 335-342;

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Valproate Protective Effects on Cisplatin-induced Peripheral Neuropathy: An In Vitro and In Vivo Study
VIRGINIA RODRIGUEZ-MENENDEZ, ALESSANDRA GILARDINI, MARIO BOSSI, ANNALISA CANTA, NORBERTO OGGIONI, VALENTINA CAROZZI, LUCIO TREMOLIZZO, GUIDO CAVALETTI
Anticancer Research Jan 2008, 28 (1A) 335-342;
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