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Research ArticleExperimental Studies

The Interleukin-10 (-1082A/G) Polymorphism is Strongly Associated with Increased Risk for Oral Squamous Cell Carcinoma

ELEFTHERIOS VAIRAKTARIS, CHRISTOS YAPIJAKIS, ZOE SEREFOGLOU, SPYRIDOULA DERKA, STAVROS VASSILIOU, EMEKA NKENKE, ANTONIS VYLLIOTIS, SOFIA SPYRIDONIDOU, FRIEDRICH W. NEUKAM, KARL A. SCHLEGEL and EFSTRATIOS PATSOURIS
Anticancer Research January 2008, 28 (1A) 309-314;
ELEFTHERIOS VAIRAKTARIS
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  • For correspondence: lvairakt@med.uoa.gr
CHRISTOS YAPIJAKIS
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ZOE SEREFOGLOU
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SPYRIDOULA DERKA
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STAVROS VASSILIOU
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EMEKA NKENKE
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ANTONIS VYLLIOTIS
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SOFIA SPYRIDONIDOU
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FRIEDRICH W. NEUKAM
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KARL A. SCHLEGEL
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EFSTRATIOS PATSOURIS
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Abstract

Background: Increased levels of interleukin-10 (IL-10) have been observed in patients with oral cancer, possibly as a result of suppression of the immune response. Based on this, the -1082A/G polymorphism, which influences IL-10 gene expression level, was investigated in regard to its possible association with risk for oral cancer. Patients and Methods: The polymorphism was examined in DNA samples of 144 patients with oral squamous cell carcinoma and 141 healthy controls of equivalent gender, age and ethnicity. Results: The detected allele frequencies for the high expression G allele were significantly higher in patients compared to controls (34.7% versus 21.3%, respectively, p=0.0004), as well as in patients that were smokers but not those that were heavy alcohol consumers. This highly significant difference in G allele frequency was mainly due to the increase of AG heterozygotes in patients compared to controls (OR 3.05, 95% CI 1.84-5.05). Conclusion: These findings suggest that the high expression G allele of the -1082A/G polymorphism of the inflammation and angiogenesis-related IL-10 is strongly associated with increased risk for oral cancer.

  • Interleukin-10
  • oral cancer
  • inflammation
  • angiogenesis
  • thrombophilia

Footnotes

  • ↵* Both authors contributed equally to this study.

  • Received September 14, 2007.
  • Revision received November 6, 2007.
  • Accepted November 20, 2007.
  • Copyright© 2008 International Institute of Anticaner Research (Dr. John G. Delinassios), All rights reserved
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Anticancer Research: 28 (1A)
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The Interleukin-10 (-1082A/G) Polymorphism is Strongly Associated with Increased Risk for Oral Squamous Cell Carcinoma
ELEFTHERIOS VAIRAKTARIS, CHRISTOS YAPIJAKIS, ZOE SEREFOGLOU, SPYRIDOULA DERKA, STAVROS VASSILIOU, EMEKA NKENKE, ANTONIS VYLLIOTIS, SOFIA SPYRIDONIDOU, FRIEDRICH W. NEUKAM, KARL A. SCHLEGEL, EFSTRATIOS PATSOURIS
Anticancer Research Jan 2008, 28 (1A) 309-314;

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The Interleukin-10 (-1082A/G) Polymorphism is Strongly Associated with Increased Risk for Oral Squamous Cell Carcinoma
ELEFTHERIOS VAIRAKTARIS, CHRISTOS YAPIJAKIS, ZOE SEREFOGLOU, SPYRIDOULA DERKA, STAVROS VASSILIOU, EMEKA NKENKE, ANTONIS VYLLIOTIS, SOFIA SPYRIDONIDOU, FRIEDRICH W. NEUKAM, KARL A. SCHLEGEL, EFSTRATIOS PATSOURIS
Anticancer Research Jan 2008, 28 (1A) 309-314;
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