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Research ArticleExperimental Studies

Identification of Glutathione Sulfotransferase-π (GSTP1) as a New Resveratrol Targeting Protein (RTP) and Studies of Resveratrol-responsive Protein Changes by Resveratrol Affinity Chromatography

TZE-CHEN HSIEH, ZHIRONG WANG, HAITENG DENG and JOSEPH M. WU
Anticancer Research January 2008, 28 (1A) 29-36;
TZE-CHEN HSIEH
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ZHIRONG WANG
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HAITENG DENG
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JOSEPH M. WU
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  • For correspondence: Joseph_Wu@nymc.edu
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Abstract

Background: Resveratrol shows chemopreventive and other biological affects in in vitro and some animal studies. The bioactivities of resveratrol may be attributed to qualitative and quantitative differences in its cell-type-specific interaction and binding with its cellular targets, denoted as resveratrol targeting proteins (RTPs). Materials and Methods: To isolate RTPs, resveratrol was linked to epoxy-activated agarose generating an affinity platform to allow the isolation, purification, and characterization of distinct RTPs from cultured prostate cancer cell extracts. Results: Glutathione sulfotransferase-π (GSTP1) and estrogen receptor-β, (ER-β) were found to be new RTPs. Resveratrol affinity chromatography was shown to be an easy method for analyzing resveratrol-responsive protein changes in the androgen-dependent LNCaP cells. Conclusion: Resveratrol affects cellular functions at multiple levels, ranging from interaction with detoxification enzymes, such as GSTP1 and transcription by targeting factors such as ER-β.

  • Biospecific column chromatography
  • RTPs
  • GSTP1
  • ER-β
  • resveratrol
  • glutathione sulfotransferase-π
  • Received September 17, 2007.
  • Revision received November 16, 2007.
  • Accepted December 10, 2007.
  • Copyright© 2008 International Institute of Anticaner Research (Dr. John G. Delinassios), All rights reserved
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Anticancer Research: 28 (1A)
Anticancer Research
Vol. 28, Issue 1A
January-February 2008
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Identification of Glutathione Sulfotransferase-π (GSTP1) as a New Resveratrol Targeting Protein (RTP) and Studies of Resveratrol-responsive Protein Changes by Resveratrol Affinity Chromatography
TZE-CHEN HSIEH, ZHIRONG WANG, HAITENG DENG, JOSEPH M. WU
Anticancer Research Jan 2008, 28 (1A) 29-36;

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Identification of Glutathione Sulfotransferase-π (GSTP1) as a New Resveratrol Targeting Protein (RTP) and Studies of Resveratrol-responsive Protein Changes by Resveratrol Affinity Chromatography
TZE-CHEN HSIEH, ZHIRONG WANG, HAITENG DENG, JOSEPH M. WU
Anticancer Research Jan 2008, 28 (1A) 29-36;
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