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Research ArticleExperimental Studies

Antiangiogenic Properties of Lupulone, a Bitter Acid of Hop Cones

LUZ SIEGEL, ANNE MITERNIQUE-GROSSE, CHRISTIAN GRIFFON, CLAUDINE KLEIN-SOYER, ANNELISE LOBSTEIN, FRANCIS RAUL and DOMINIQUE STEPHAN
Anticancer Research January 2008, 28 (1A) 289-294;
LUZ SIEGEL
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ANNE MITERNIQUE-GROSSE
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CHRISTIAN GRIFFON
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CLAUDINE KLEIN-SOYER
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ANNELISE LOBSTEIN
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FRANCIS RAUL
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  • For correspondence: francis.raul@ircad.u-strasbg.fr
DOMINIQUE STEPHAN
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Abstract

Background: Angiogenesis is the result of intricate steps regulated by the balance between agonistic and antagonistic effectors. Disturbance of this balance leads to an ‘angiogenic’ switch critical for tumor development. Materials and Methods: Using human umbilical vein endothelial cells (HUVEC) the effects of lupulone were analyzed on proliferation induced by angiogenic growth factors, transmembrane cell migration toward fibronectin and formation of a network of tubular-like structures on Matrigel. Results: Lupulone (2.5-50 μg/ml) induced a concentration-dependent inhibition of HUVEC proliferation and chemotaxis. Lupulone caused a significant reduction of closed capillary-like structures in Matrigel indicating a strong inhibitory effect on neovascularisation. In mice receiving lupulone (20 mg/kg/day) in drinking water for 21 days, new vessel formation was reduced by 50% in matrigel plugs implanted under the skin when compared with controls. Conclusion: The present data demonstrate that lupulone is able to inhibit angiogenesis in vitro and in vivo. Lupulone emerges as a potential chemopreventive agent when considering its strong antiangiogenic properties.

  • Hop beta-acids
  • angiogenesis
  • angioprevention
  • cell proliferation
  • chemotaxis
  • VEGF
  • matrigel plug
  • Received July 16, 2007.
  • Revision received October 16, 2007.
  • Accepted October 30, 2007.
  • Copyright© 2008 International Institute of Anticaner Research (Dr. John G. Delinassios), All rights reserved
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Anticancer Research: 28 (1A)
Anticancer Research
Vol. 28, Issue 1A
January-February 2008
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Antiangiogenic Properties of Lupulone, a Bitter Acid of Hop Cones
LUZ SIEGEL, ANNE MITERNIQUE-GROSSE, CHRISTIAN GRIFFON, CLAUDINE KLEIN-SOYER, ANNELISE LOBSTEIN, FRANCIS RAUL, DOMINIQUE STEPHAN
Anticancer Research Jan 2008, 28 (1A) 289-294;

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Antiangiogenic Properties of Lupulone, a Bitter Acid of Hop Cones
LUZ SIEGEL, ANNE MITERNIQUE-GROSSE, CHRISTIAN GRIFFON, CLAUDINE KLEIN-SOYER, ANNELISE LOBSTEIN, FRANCIS RAUL, DOMINIQUE STEPHAN
Anticancer Research Jan 2008, 28 (1A) 289-294;
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