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Research ArticleExperimental Studies

A New Single Nucleotide Polymorphism in XRCC4 Gene is Associated with Breast Cancer Susceptibility in Taiwanese Patients

CHANG-FANG CHIU, HWEI-CHUNG WANG, CHUNG-HSING WANG, CHENG-LI WANG, CHENG-CHIEH LIN, CHEN-YANG SHEN, SU-YIN CHIANG and DA-TIAN BAU
Anticancer Research January 2008, 28 (1A) 267-270;
CHANG-FANG CHIU
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HWEI-CHUNG WANG
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CHUNG-HSING WANG
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CHENG-LI WANG
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CHENG-CHIEH LIN
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CHEN-YANG SHEN
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SU-YIN CHIANG
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DA-TIAN BAU
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  • For correspondence: datian@www.cmuh.org.tw
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Abstract

Background: The DNA repair gene XRCC4, an important caretaker of the overall genome stability, is thought to play a major role in the human carcinogenesis. Some new and important polymorphic variants of XRCC4, at codon 247 (rs 3734091), G-1394T (rs 6869366), and Intron 7 (rs 28360317), and their association with breast cancer susceptibility was investigated in a Taiwanese population. Materials and Methods: In a hospital-based case-control study, 432 female patients with breast cancer and 432 age-matched healthy controls recruited from the China Medical Hospital in Central Taiwan were genotyped. Results: A significant difference in the frequency of the XRCC4 G-1394T genotype, but not the XRCC4 codon 247, or intron 7 genotypes was found between the breast cancer and control groups. Individuals with G/T or T/T at the XRCC4 G-1394T locus showed a 2.33-fold (95% confidence interval=1.37-3.98) increased risk of breast cancer compared to those with G/G. For XRCC4 codon 247 or intron 7, there was no difference in distribution between the breast cancer and control groups. Conclusion: Our findings suggest that the heterozygous and homozygous T allele of the XRCC4 G-1394T may be associated with the development of breast cancer and may be a useful biomarker for anticancer prevention and intervention.

  • XRCC4
  • polymorphism
  • breast cancer
  • carcinogenesis

Footnotes

  • ↵* Both authors contributed equally to this work.

  • Received June 27, 2007.
  • Revision received October 25, 2007.
  • Accepted November 1, 2007.
  • Copyright© 2008 International Institute of Anticaner Research (Dr. John G. Delinassios), All rights reserved
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Anticancer Research: 28 (1A)
Anticancer Research
Vol. 28, Issue 1A
January-February 2008
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A New Single Nucleotide Polymorphism in XRCC4 Gene is Associated with Breast Cancer Susceptibility in Taiwanese Patients
CHANG-FANG CHIU, HWEI-CHUNG WANG, CHUNG-HSING WANG, CHENG-LI WANG, CHENG-CHIEH LIN, CHEN-YANG SHEN, SU-YIN CHIANG, DA-TIAN BAU
Anticancer Research Jan 2008, 28 (1A) 267-270;

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A New Single Nucleotide Polymorphism in XRCC4 Gene is Associated with Breast Cancer Susceptibility in Taiwanese Patients
CHANG-FANG CHIU, HWEI-CHUNG WANG, CHUNG-HSING WANG, CHENG-LI WANG, CHENG-CHIEH LIN, CHEN-YANG SHEN, SU-YIN CHIANG, DA-TIAN BAU
Anticancer Research Jan 2008, 28 (1A) 267-270;
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