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Research ArticleExperimental Studies

PAI-1, t-PA and Circulating hTERT DNA as Related to Virus Infection in Liver Carcinogenesis

ROSA DIVELLA, ROSANNA LACALAMITA, STEFANIA TOMMASI, MARIA COVIELLO, ANTONELLA DANIELE, VITO MICHELE GARRISI, INES ABBATE, GIOVANNI SIMONE, COSIMO GADALETA, ANGELO PARADISO and MICHELE QUARANTA
Anticancer Research January 2008, 28 (1A) 223-228;
ROSA DIVELLA
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ROSANNA LACALAMITA
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STEFANIA TOMMASI
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MARIA COVIELLO
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ANTONELLA DANIELE
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VITO MICHELE GARRISI
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INES ABBATE
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GIOVANNI SIMONE
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COSIMO GADALETA
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ANGELO PARADISO
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MICHELE QUARANTA
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  • For correspondence: michelequaranta@virgilio.it rosadive@inwind.it
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Abstract

Background: Liver carcinogenesis seems to be heavely influenced by hepatitis B and C viral (HBV, HCV) infection. The aim of our study was to improve the detection of hepatocellular carcinoma (HCC) by measuring alfa-fetoprotein (AFP) in addition to other molecular markers by estimating the plasma levels of human catalytic fraction of reverse telomerase (hTERT) DNA, plasminogen activator inhibitor-1 (PAI-1) and tissue plasminogen activator (t-PA) in 75 patients with liver desease. Patients and Methods: A control group was enrolled (N=30). PAI-1 and t-PA levels were detected with enzyme-linked immunoassorbent assay (ELISA), DNA hTERT was performed with real time polymerase chain reaction (RT-PCR). Results: PAI-1, t-PA and hTERT DNA levels were much higher than in controls. PAI-1 and t-PA levels were higher in the presence of both viruses compared to their absence, p<0.001. Moreover, hTERT was significantly higher in the presence of both viruses, p<0.05 and in the presence of HCV alone, p<0.05. No decrease or increase of AFP was noted in these patients. Conclusion: Our data suggest the reliability of PAI-1, t-PA and hTERT in detecting HCC, in particular when the carcinogenesis is affected by virus infection.

  • Hepatocellular carcinoma
  • circulating hTERT DNA
  • PAI-1
  • t-PA
  • Received September 25, 2007.
  • Revision received November 26, 2007.
  • Accepted December 11, 2007.
  • Copyright© 2008 International Institute of Anticaner Research (Dr. John G. Delinassios), All rights reserved
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Anticancer Research: 28 (1A)
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PAI-1, t-PA and Circulating hTERT DNA as Related to Virus Infection in Liver Carcinogenesis
ROSA DIVELLA, ROSANNA LACALAMITA, STEFANIA TOMMASI, MARIA COVIELLO, ANTONELLA DANIELE, VITO MICHELE GARRISI, INES ABBATE, GIOVANNI SIMONE, COSIMO GADALETA, ANGELO PARADISO, MICHELE QUARANTA
Anticancer Research Jan 2008, 28 (1A) 223-228;

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PAI-1, t-PA and Circulating hTERT DNA as Related to Virus Infection in Liver Carcinogenesis
ROSA DIVELLA, ROSANNA LACALAMITA, STEFANIA TOMMASI, MARIA COVIELLO, ANTONELLA DANIELE, VITO MICHELE GARRISI, INES ABBATE, GIOVANNI SIMONE, COSIMO GADALETA, ANGELO PARADISO, MICHELE QUARANTA
Anticancer Research Jan 2008, 28 (1A) 223-228;
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