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Research ArticleExperimental Studies

Frequent Splicing Aberration of the Base Excision Repair Gene hMYH in Human Gastric Cancer

KATSUTOSHI KOBAYASHI, ATSUO SHIDA, HISASHI YAMADA, YOSHIO ISHIBASHI, RITSUKO NAKAYAMA, YASUO TORIUMI, NORIO MITSUMORI, HIDEYUKI KASHIWAGI and KATSUHIKO YANAGA
Anticancer Research January 2008, 28 (1A) 215-221;
KATSUTOSHI KOBAYASHI
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  • For correspondence: caseysurg@violin.ocn.ne.jp
ATSUO SHIDA
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HISASHI YAMADA
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YOSHIO ISHIBASHI
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RITSUKO NAKAYAMA
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YASUO TORIUMI
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NORIO MITSUMORI
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HIDEYUKI KASHIWAGI
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KATSUHIKO YANAGA
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Abstract

Background: Missense mutation of hMYH, which prevents transversion mutations induced by oxidative DNA damage, is reportedly associated with the development of gastric and colon cancer. We investigated whether deficiency or mutation of hMYH is associated with gastric carcinogenesis. Patients and Methods: Thirty patients with gastric carcinoma, three gastric cancer cell lines and lymphocytes from three healthy volunteers were investigated. Reverse transcription-polymerase chain reaction (RT-PCR) was performed for hMYH, and the full-length sequence of hMYH mRNA was analysed. Results: A silent mutation at codon 473 was seen in two tumours. Single nucleotide polymorphism at codon 345 was observed in 14 patients. These two base substitutions had no pathogenic effect. Seven splice variants were observed and two aberrant transcripts were detected more frequently in cancer specimens (67%) than in normal mucosa (10%). Conclusion: The high frequency of splicing aberration in cancer tissues suggests that aberrant transcripts may be involved in gastric carcinogenesis and cancer development.

  • Gastric cancer
  • DNA repair
  • oxidative DNA damage

Footnotes

  • ↵* The first two authors should be regarded as joint First Authors.

  • Received August 22, 2007.
  • Revision received November 6, 2007.
  • Accepted December 11, 2007.
  • Copyright© 2008 International Institute of Anticaner Research (Dr. John G. Delinassios), All rights reserved
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Anticancer Research: 28 (1A)
Anticancer Research
Vol. 28, Issue 1A
January-February 2008
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Frequent Splicing Aberration of the Base Excision Repair Gene hMYH in Human Gastric Cancer
KATSUTOSHI KOBAYASHI, ATSUO SHIDA, HISASHI YAMADA, YOSHIO ISHIBASHI, RITSUKO NAKAYAMA, YASUO TORIUMI, NORIO MITSUMORI, HIDEYUKI KASHIWAGI, KATSUHIKO YANAGA
Anticancer Research Jan 2008, 28 (1A) 215-221;

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Frequent Splicing Aberration of the Base Excision Repair Gene hMYH in Human Gastric Cancer
KATSUTOSHI KOBAYASHI, ATSUO SHIDA, HISASHI YAMADA, YOSHIO ISHIBASHI, RITSUKO NAKAYAMA, YASUO TORIUMI, NORIO MITSUMORI, HIDEYUKI KASHIWAGI, KATSUHIKO YANAGA
Anticancer Research Jan 2008, 28 (1A) 215-221;
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