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Research ArticleExperimental Studies

Chemotherapy-induced Bystander Effect in Response to Several Chloroethylnitrosoureas: An Origin Independent of DNA Damage?

PATRICK MERLE, DANIEL MORVAN, DENIS CAILLAUD and AICHA DEMIDEM
Anticancer Research January 2008, 28 (1A) 21-27;
PATRICK MERLE
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DANIEL MORVAN
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DENIS CAILLAUD
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AICHA DEMIDEM
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  • For correspondence: demidem@inserm484.u-clermont1.fr
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Abstract

Chloroethylnitrosourea (CENU) chemotherapy is used for the treatment of melanoma tumors. The main mechanism of action of this anticancer agent is via DNA damage. We recently showed in murine experiments using a parental double B16 melanoma tumor model that, after treatment of primary tumors with cystemustine (CENU agent), untreated secondary tumors exhibited growth inhibition and metabolism disorders. The response of secondary untreated tumor was called the chemotherapy-induced bystander effect. To see whether chemotherapy-induced bystander effects were induced with other members of the CENU family, we compared three CENU(s) used in melanoma treatment: cystemustine, carmustine and fotemustine. Our results demonstrate that fotemustine, like cystemustine, but not carmustine induced a protective effect against secondary untreated tumors including alterations in phospholipid derivative and glutathione which are the metabolic signature of the bystander effect. From these data we may conclude that DNA damage to the primary tumor is not sufficient to explain chemotherapy-induced bystander effects.

  • Chloroethylnitrosoureas
  • melanoma
  • bystander effect
  • murine type
  • NMR spectroscopy
  • Received July 12, 2007.
  • Revision received October 22, 2007.
  • Accepted November 29, 2007.
  • Copyright© 2008 International Institute of Anticaner Research (Dr. John G. Delinassios), All rights reserved
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Anticancer Research: 28 (1A)
Anticancer Research
Vol. 28, Issue 1A
January-February 2008
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Chemotherapy-induced Bystander Effect in Response to Several Chloroethylnitrosoureas: An Origin Independent of DNA Damage?
PATRICK MERLE, DANIEL MORVAN, DENIS CAILLAUD, AICHA DEMIDEM
Anticancer Research Jan 2008, 28 (1A) 21-27;

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Chemotherapy-induced Bystander Effect in Response to Several Chloroethylnitrosoureas: An Origin Independent of DNA Damage?
PATRICK MERLE, DANIEL MORVAN, DENIS CAILLAUD, AICHA DEMIDEM
Anticancer Research Jan 2008, 28 (1A) 21-27;
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