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Research ArticleExperimental Studies

Overexpression of the Mitotic Spindle Assembly Checkpoint Genes hBUB1, hBUBR1 and hMAD2 in Thyroid Carcinomas with Aggressive Nature

NOBUYUKI WADA, AKIRA YOSHIDA, YOHEI MIYAGI, TOSHIHARU YAMAMOTO, HIROTAKA NAKAYAMA, NOBUYASU SUGANUMA, KENICHI MATSUZU, KATSUHIKO MASUDO, SHOHEI HIRAKAWA, YASUSHI RINO, MUNETAKA MASUDA and TOSHIO IMADA
Anticancer Research January 2008, 28 (1A) 139-144;
NOBUYUKI WADA
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  • For correspondence: Wadan523@aol.com
AKIRA YOSHIDA
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YOHEI MIYAGI
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TOSHIHARU YAMAMOTO
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HIROTAKA NAKAYAMA
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NOBUYASU SUGANUMA
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KENICHI MATSUZU
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KATSUHIKO MASUDO
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SHOHEI HIRAKAWA
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YASUSHI RINO
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MUNETAKA MASUDA
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TOSHIO IMADA
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Abstract

Background: The mitotic spindle assembly checkpoint (MSAC) genes are responsible for preventing chromosome missegregation. MSAC gene expressions have been reported to be associated with tumor cell proliferation or unfavorable cancer behavior. The present study was conducted to preliminary investigate the MSAC gene expressions in thyroid neoplasms. Materials and Methods: Expression levels of MSAC genes (hBUB1, hBUBR1, hBUB3 and hMAD2) were evaluated in 9 follicular thyroid adenomas (FAs), 9 follicular thyroid carcinomas (FTCs), 21 papillary thyroid carcinomas (PTCs), 5 anaplastic (undifferentiated) thyroid carcinomas (ATCs) and 3 adjacent normal thyroid tissues (NTs) by real-time quantitative RT-PCR. These gene expressions were compared between undifferentiated thyroid carcinomas (ATCs) and differentiated thyroid carcinomas (DTCs) and between advanced DTCs and non-advanced DTCs. DTCs included PTCs and FTCs. Advanced DTCs were defined as carcinoma with aggressive nature such as extrathyroid extension, distant metastasis, recurrence or death from the disease. Results: MSAC gene expressions varied in different thyroid tumors and fell in the order of ATC, DTC (PTC and FTC), FA and NT. Carcinomas had higher expression compared to adenoma or normal tissue. hBUB1, hBUBR1 and hMAD2 expressions in ATCs were significantly higher than those in DTCs (p<0.005). hBUBR1 and hMAD2 expressions in advanced DTCs were significantly higher than those in non-advanced DTCs (p<0.05). Conclusion: The MSAC genes were overexpressed in thyroid carcinomas with aggressive nature. Further studies are required to clarify the relationship between the MSAC gene expressions and thyroid cancer behavior.

  • Mitotic spindle assembly checkpoint
  • thyroid carcinoma
  • tumor aggressiveness
  • Received July 12, 2007.
  • Revision received October 30, 2007.
  • Accepted November 15, 2007.
  • Copyright© 2008 International Institute of Anticaner Research (Dr. John G. Delinassios), All rights reserved
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Anticancer Research: 28 (1A)
Anticancer Research
Vol. 28, Issue 1A
January-February 2008
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Overexpression of the Mitotic Spindle Assembly Checkpoint Genes hBUB1, hBUBR1 and hMAD2 in Thyroid Carcinomas with Aggressive Nature
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Overexpression of the Mitotic Spindle Assembly Checkpoint Genes hBUB1, hBUBR1 and hMAD2 in Thyroid Carcinomas with Aggressive Nature
NOBUYUKI WADA, AKIRA YOSHIDA, YOHEI MIYAGI, TOSHIHARU YAMAMOTO, HIROTAKA NAKAYAMA, NOBUYASU SUGANUMA, KENICHI MATSUZU, KATSUHIKO MASUDO, SHOHEI HIRAKAWA, YASUSHI RINO, MUNETAKA MASUDA, TOSHIO IMADA
Anticancer Research Jan 2008, 28 (1A) 139-144;

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Overexpression of the Mitotic Spindle Assembly Checkpoint Genes hBUB1, hBUBR1 and hMAD2 in Thyroid Carcinomas with Aggressive Nature
NOBUYUKI WADA, AKIRA YOSHIDA, YOHEI MIYAGI, TOSHIHARU YAMAMOTO, HIROTAKA NAKAYAMA, NOBUYASU SUGANUMA, KENICHI MATSUZU, KATSUHIKO MASUDO, SHOHEI HIRAKAWA, YASUSHI RINO, MUNETAKA MASUDA, TOSHIO IMADA
Anticancer Research Jan 2008, 28 (1A) 139-144;
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