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Research ArticleExperimental Studies

Wilms' Tumor 1 Protein and Focal Adhesion Kinase Mediate Keratinocyte Growth Factor Signaling in Breast Cancer Cells

XIAO-PING ZANG, J. THOMAS PENTO and ANA M. TARI
Anticancer Research January 2008, 28 (1A) 133-137;
XIAO-PING ZANG
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J. THOMAS PENTO
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ANA M. TARI
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  • For correspondence: atari@mdanderson.org
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Abstract

Background: Keratinocyte growth factor (KGF) has been shown to induce breast cancer metastasis in animal models. cDNA microarrays have revealed that KGF increased Wilms tumor 1 (WT1) and focal adhesion kinase (FAK) expression in breast cancer cells. The role of WT1 and FAK in KGF signaling was investigated. Materials and Methods: A cell culture wounding model was used to study the effects of WT1 and FAK down-regulation on KGF-induced proliferation and motility in breast cancer cells. Results: WT1 down-regulation inhibited KGF-mediated proliferation and motility of breast cancer cells, while FAK down-regulation inhibited proliferation, but had no significant effect on cell motility. WT1 down-regulation, but not FAK down-regulation, led to Erk1,2 inactivation. Conclusion: KGF-mediated signaling employs WT1 and FAK to regulate breast cancer cell proliferation and motility and may represent therapeutic targets for the prevention of breast cancer progression.

  • KGF
  • WT1
  • FAK
  • Grb2
  • Erk1,2
  • breast cancer cell motility
  • Received June 29, 2007.
  • Revision received September 27, 2007.
  • Accepted October 26, 2007.
  • Copyright© 2008 International Institute of Anticaner Research (Dr. John G. Delinassios), All rights reserved
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Anticancer Research: 28 (1A)
Anticancer Research
Vol. 28, Issue 1A
January-February 2008
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Wilms' Tumor 1 Protein and Focal Adhesion Kinase Mediate Keratinocyte Growth Factor Signaling in Breast Cancer Cells
XIAO-PING ZANG, J. THOMAS PENTO, ANA M. TARI
Anticancer Research Jan 2008, 28 (1A) 133-137;

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Wilms' Tumor 1 Protein and Focal Adhesion Kinase Mediate Keratinocyte Growth Factor Signaling in Breast Cancer Cells
XIAO-PING ZANG, J. THOMAS PENTO, ANA M. TARI
Anticancer Research Jan 2008, 28 (1A) 133-137;
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