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Research ArticleExperimental Studies

Effects of α-Santalol on Proapoptotic Caspases and p53 Expression in UVB Irradiated Mouse Skin

BHANU L. ARASADA, AJAY BOMMAREDDY, XIAOYING ZHANG, KATHRYN BREMMON and CHANDRADHAR DWIVEDI
Anticancer Research January 2008, 28 (1A) 129-132;
BHANU L. ARASADA
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AJAY BOMMAREDDY
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XIAOYING ZHANG
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KATHRYN BREMMON
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CHANDRADHAR DWIVEDI
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  • For correspondence: Chandradhar.Dwivedi@sdstate.edu
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Abstract

Background: Cancer chemoprevention by naturally occurring agents, especially phytochemicals, minerals and vitamins has shown promising results against various malignancies in a number of studies both under in vitro and in vivo conditions. One such phytochemical, α-santalol, a major component of sandalwood oil, is effective in preventing skin cancer in both chemically and UVB-induced skin cancer development in CD-1, SENCAR and SKH-1 mice; however, the mechanism of its efficacy is not fully understood. The objective of the present investigation was to study the effects of α-santalol on apoptosis proteins and p53 in UVB-induced skin tumor development in SKH-1 mice to elucidate the mechanism of action. Materials and Methods: Female SKH-1 mice were divided into two groups: Group 1, which served as control received topical application of acetone (0.1 ml) one hour before UVB treatment; Group 2 received α-santalol (0.1 ml, 5% w/v in acetone, topical) one hour prior to UVB treatment. UVB-induced promotion was continued for 30 weeks. Results: Pretreatment with α-santalol one hour prior to UVB exposure significantly (p<0.05) reduced tumor incidence and multiplicity, and resulted in a significant (p<0.05) increase in apoptosis proteins, caspase-3 and -8 levels and tumor suppressor protein, p53. Conclusion: These results suggest that α-santalol prevents skin cancer development by inducing proapoptotic proteins via an extrinsic pathway and increasing p53.

  • α-Santalol
  • caspases
  • p53
  • UVB radiation
  • skin cancer
  • Received July 19, 2007.
  • Revision received November 13, 2007.
  • Accepted December 12, 2007.
  • Copyright© 2008 International Institute of Anticaner Research (Dr. John G. Delinassios), All rights reserved
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Anticancer Research: 28 (1A)
Anticancer Research
Vol. 28, Issue 1A
January-February 2008
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Effects of α-Santalol on Proapoptotic Caspases and p53 Expression in UVB Irradiated Mouse Skin
BHANU L. ARASADA, AJAY BOMMAREDDY, XIAOYING ZHANG, KATHRYN BREMMON, CHANDRADHAR DWIVEDI
Anticancer Research Jan 2008, 28 (1A) 129-132;

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Effects of α-Santalol on Proapoptotic Caspases and p53 Expression in UVB Irradiated Mouse Skin
BHANU L. ARASADA, AJAY BOMMAREDDY, XIAOYING ZHANG, KATHRYN BREMMON, CHANDRADHAR DWIVEDI
Anticancer Research Jan 2008, 28 (1A) 129-132;
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