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Research ArticleExperimental Studies

EpCAM Overexpression is Associated with High-grade Urothelial Carcinoma in the Renal Pelvis

ANDREA BRUNNER, GEORG SCHAEFER, LOTHAR VEITS, BARBARA BRUNNER, MARTINA PRELOG and CHRISTIAN ENSINGER
Anticancer Research January 2008, 28 (1A) 125-128;
ANDREA BRUNNER
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  • For correspondence: andrea.brunner@i-med.ac.at
GEORG SCHAEFER
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LOTHAR VEITS
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BARBARA BRUNNER
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MARTINA PRELOG
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CHRISTIAN ENSINGER
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Abstract

Background: EpCAM serves as an attractive target for immunotherapy due to its expression on the surface of most epithelial cancer cells. Urothelial carcinoma of the renal pelvis (RP-UC) comprises 2.4-4.6% of tumors of the lower urinary tract. To assess the expression of EpCAM in RP-UC a retrospective study was performed. Patients and Methods: Tumor tissue from 42 patients with RP-UC was selected from the archives of the Institute of Pathology, Medical University of Innsbruck, Austria. EpCAM expression was demonstrated by immunohistochemistry using the mouse monoclonal antibody ESA. Results: EpCAM overexpression was significantly associated with high grade and invasive behaviour (p=0.014 and p=0.029) and the presence of lymph node metastases (p=0.031), but not with the extent of nodal involvement (p=0.12). Conclusion: In RP-UC, EpCAM overexpression is associated with an aggressive tumor phenotype. The association of EpCAM overexpression with the presence of lymph node metastasis may be of prognostic and therapeutic relevance.

  • EpCAM
  • urothelial cancer
  • renal pelvis
  • Received September 14, 2007.
  • Revision received November 15, 2007.
  • Accepted December 11, 2007.
  • Copyright© 2008 International Institute of Anticaner Research (Dr. John G. Delinassios), All rights reserved
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Anticancer Research: 28 (1A)
Anticancer Research
Vol. 28, Issue 1A
January-February 2008
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EpCAM Overexpression is Associated with High-grade Urothelial Carcinoma in the Renal Pelvis
ANDREA BRUNNER, GEORG SCHAEFER, LOTHAR VEITS, BARBARA BRUNNER, MARTINA PRELOG, CHRISTIAN ENSINGER
Anticancer Research Jan 2008, 28 (1A) 125-128;

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EpCAM Overexpression is Associated with High-grade Urothelial Carcinoma in the Renal Pelvis
ANDREA BRUNNER, GEORG SCHAEFER, LOTHAR VEITS, BARBARA BRUNNER, MARTINA PRELOG, CHRISTIAN ENSINGER
Anticancer Research Jan 2008, 28 (1A) 125-128;
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