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Research ArticleClinical Studies

Further Studies on Serrated Neoplasias of the Cardia: A Review and Case Report

CARLOS A. RUBIO, FREDRIK PETERSSON, ANDERS HÖÖG, JÓN G. JÓNASSON, GABRIELLA NESI, EVANGELOS CHANDANOS and MATS LINDBLAD
Anticancer Research November 2007, 27 (6C) 4431-4434;
CARLOS A. RUBIO
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  • For correspondence: Carlos.Rubio@ki.se
FREDRIK PETERSSON
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ANDERS HÖÖG
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JÓN G. JÓNASSON
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GABRIELLA NESI
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EVANGELOS CHANDANOS
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MATS LINDBLAD
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Abstract

We have previously recorded 6 cases of serrated adenoma in the cardia. Here we report a case, which differed cytologically from the 6 preceding cases in as much as the adenomatous cells had clear, micro-vacuolated cytoplasm and secreted neutral mucins. Similar cellular features found in gastric carcinomas were classified by Mulligan as of pylorocardiac gland cell type. Six of the 7 cases (including the one reported here) showed areas of invasive carcinoma. Because of its location, histological and histochemical features, the reported neoplasia was called serrated adenoma malignum of the cardia (Mulligan type). Serrated adenomas of the cardia seem to have a particular proclivity to evolve into invasive carcinomas.

  • Gastric
  • neoplasia
  • serrated
  • pylorocardiac type

Footnotes

  • Received July 25, 2007.
  • Revision received September 28, 2007.
  • Copyright© 2007 International Institute of Anticancer Research (Dr. John G. Delinassios), All rights reserved
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Anticancer Research: 27 (6C)
Anticancer Research
Vol. 27, Issue 6C
November-December 2007
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Further Studies on Serrated Neoplasias of the Cardia: A Review and Case Report
CARLOS A. RUBIO, FREDRIK PETERSSON, ANDERS HÖÖG, JÓN G. JÓNASSON, GABRIELLA NESI, EVANGELOS CHANDANOS, MATS LINDBLAD
Anticancer Research Nov 2007, 27 (6C) 4431-4434;

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Further Studies on Serrated Neoplasias of the Cardia: A Review and Case Report
CARLOS A. RUBIO, FREDRIK PETERSSON, ANDERS HÖÖG, JÓN G. JÓNASSON, GABRIELLA NESI, EVANGELOS CHANDANOS, MATS LINDBLAD
Anticancer Research Nov 2007, 27 (6C) 4431-4434;
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