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Research ArticleClinical Studies

High Incidence of GalNAc Disialosyl Lactotetraosylceramide in Metastatic Renal Cell Carcinoma

RYO MARUYAMA, SEIICHI SAITO, VLADIMIR BILIM, NOBORU HARA, TOSHIYUKI ITOI, KAZUTOSHI YAMANA, TSUTOMU NISHIYAMA, YOICHI ARAI, KOTA TAKAHASHI and YOSHIHIKO TOMITA
Anticancer Research November 2007, 27 (6C) 4345-4350;
RYO MARUYAMA
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SEIICHI SAITO
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VLADIMIR BILIM
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NOBORU HARA
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TOSHIYUKI ITOI
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KAZUTOSHI YAMANA
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TSUTOMU NISHIYAMA
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YOICHI ARAI
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KOTA TAKAHASHI
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YOSHIHIKO TOMITA
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  • For correspondence: ytomita@med.id.yamagata-u.ac.jp
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Abstract

Background: In renal cell carcinoma (RCC), glycosphingolipids monosialosyl globopentaosylceramide (MSGb5) and GalNAc disialosyl lactotetraosylceramide (GalNAcDSLc4) were shown to be predictors of metastasis. Here we extended the research using a larger cohort of patients with a longer follow-up period, and reevaluate their relationship to malignant potential, metastasis and prognosis in patients with RCC. Patients and Methods: MSGb5 and GalNAcDSLc4 were examined in 114 primary RCCs by immunohistochemical method on cryostat sections. Results: GalNAcDSLc4 was detected in 13.2% of RCCs and was associated with a significantly higher incidence of metastasis at the time of primary visit (60.0% vs. 31.3%, p=0.0419) as well as de novo metastasis during follow-up (33.3% vs. 14.7%), and a shorter survival (p=0.0399). MSGb5 was detected in 51.8% of tumors and was not related to clinocopathological characteristics or survival. Conclusion: RCC patients with tumors positive for GalNAcDSLc4 are at higher risk of metastasis at the time of diagnosis and during follow-up.

  • Renal cell carcinoma
  • metastasis
  • glycosphingolipids

Footnotes

  • Received May 14, 2007.
  • Accepted October 4, 2007.
  • Copyright© 2007 International Institute of Anticancer Research (Dr. John G. Delinassios), All rights reserved
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Anticancer Research: 27 (6C)
Anticancer Research
Vol. 27, Issue 6C
November-December 2007
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High Incidence of GalNAc Disialosyl Lactotetraosylceramide in Metastatic Renal Cell Carcinoma
RYO MARUYAMA, SEIICHI SAITO, VLADIMIR BILIM, NOBORU HARA, TOSHIYUKI ITOI, KAZUTOSHI YAMANA, TSUTOMU NISHIYAMA, YOICHI ARAI, KOTA TAKAHASHI, YOSHIHIKO TOMITA
Anticancer Research Nov 2007, 27 (6C) 4345-4350;

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High Incidence of GalNAc Disialosyl Lactotetraosylceramide in Metastatic Renal Cell Carcinoma
RYO MARUYAMA, SEIICHI SAITO, VLADIMIR BILIM, NOBORU HARA, TOSHIYUKI ITOI, KAZUTOSHI YAMANA, TSUTOMU NISHIYAMA, YOICHI ARAI, KOTA TAKAHASHI, YOSHIHIKO TOMITA
Anticancer Research Nov 2007, 27 (6C) 4345-4350;
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