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Research ArticleClinical Studies

COX1 and COX2 Polymorphisms and Gastric Cancer Risk in a Polish Population

LIFANG HOU, PAOLO GRILLO, ZHONG-ZHENG ZHU, JOLA LISSOWSKA, MEREDITH YEAGER, WITOLD ZATONSKI, GUANSHAN ZHU, ANDREA BACCARELLI, STEPHEN J. CHANOCK, JOSEPH F. FRAUMENI and WONG-HO CHOW
Anticancer Research November 2007, 27 (6C) 4243-4247;
LIFANG HOU
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  • For correspondence: l-hou@northwestern.edu
PAOLO GRILLO
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ZHONG-ZHENG ZHU
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JOLA LISSOWSKA
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MEREDITH YEAGER
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WITOLD ZATONSKI
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GUANSHAN ZHU
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ANDREA BACCARELLI
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STEPHEN J. CHANOCK
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JOSEPH F. FRAUMENI Jr.
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WONG-HO CHOW
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Abstract

Background: Although a number of studies on the polymorphisms in COX1 and COX2 genes in association with risks for a number of cancers have been conducted, their relation to gastric cancer has not been well studied. Patients and Methods: Genotypes of several variants in both COX1 (Ex7+31 C>A and Ex10-4 G>A) and COX2 (-765 G>C, Ex10+837 T>C, Ex10-90 C>T, IVS5-275 T>G, and IVS7+111 T>C) were identified by TaqMan™ assays in 305 gastric cancer cases and 427 age- and gender-matched controls in a high-risk Polish population. Odds ratios for gastric cancer and 95% confidence intervals from unconditional logistic regression models were used to evaluate relative risks. Results: We found no statistically significant evidence that the polymorphisms tested in COX1 and COX2 are associated with gastric cancer risk. Conclusion: These results suggest that the polymorphisms examined in COX1 and COX2 do not affect the risk of gastric cancer.

  • Polymorphisms
  • COX1
  • COX2
  • gastric cancer

Footnotes

  • Received June 5, 2007.
  • Accepted August 30, 2007.
  • Copyright© 2007 International Institute of Anticancer Research (Dr. John G. Delinassios), All rights reserved
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Anticancer Research: 27 (6C)
Anticancer Research
Vol. 27, Issue 6C
November-December 2007
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COX1 and COX2 Polymorphisms and Gastric Cancer Risk in a Polish Population
LIFANG HOU, PAOLO GRILLO, ZHONG-ZHENG ZHU, JOLA LISSOWSKA, MEREDITH YEAGER, WITOLD ZATONSKI, GUANSHAN ZHU, ANDREA BACCARELLI, STEPHEN J. CHANOCK, JOSEPH F. FRAUMENI, WONG-HO CHOW
Anticancer Research Nov 2007, 27 (6C) 4243-4247;

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COX1 and COX2 Polymorphisms and Gastric Cancer Risk in a Polish Population
LIFANG HOU, PAOLO GRILLO, ZHONG-ZHENG ZHU, JOLA LISSOWSKA, MEREDITH YEAGER, WITOLD ZATONSKI, GUANSHAN ZHU, ANDREA BACCARELLI, STEPHEN J. CHANOCK, JOSEPH F. FRAUMENI, WONG-HO CHOW
Anticancer Research Nov 2007, 27 (6C) 4243-4247;
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