Abstract
The combined methylation status of p16, p14, HLTF, SOCS-1, CDH13, RUNX3 and CHFR was examined in 58 resected primary colorectal cancers using methylation-specific PCR, and the methylation status was correlated with the clinicopathological features of the affected patients. A significant difference in histology (p=0.0041) was observed when the number of methylated genes of poorly-differentiated colorectal cancers was compared to that of other differentiated ones. Poorly-differentiated colorectal cancers preferentially exhibited gene methylation.
Footnotes
- Received September 18, 2006.
- Accepted October 12, 2006.
- Copyright© 2006 International Institute of Anticancer Research (Dr. John G. Delinassios), All rights reserved