Abstract
Many university hospitals and cancer centers in Japan have actively investigated the use of autologous activated lymphocyte therapy (ALT). However its therapeutic efficacy was found to be quite limited. The efficacy of aminobisphosphonates (aBPs) has been shown for osteolytic bone disease. aBPs could activate and induce the proliferation of gamma/delta (γδ) T-cells. The application of aBPs to ALT in vivo or ex vivo may be beneficial. A brief overview of aBPs and γδ T-cells is provided, together with some preliminary results and discussion of the therapeutic potential of ALT in combination with aBPs.
Footnotes
- Received May 23, 2006.
- Revision received July 25, 2006.
- Accepted August 18, 2006.
- Copyright© 2006 International Institute of Anticancer Research (Dr. John G. Delinassios), All rights reserved
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