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Research ArticleExperimental Studies

Effect of 2-Deoxy-D-glucose on Various Malignant Cell Lines In Vitro

XIAO DONG ZHANG, EDWIGE DESLANDES, MARIE VILLEDIEU, LAURENT POULAIN, MARILYNE DUVAL, PASCAL GAUDUCHON, LAURENT SCHWARTZ and PHILIPPE ICARD
Anticancer Research September 2006, 26 (5A) 3561-3566;
XIAO DONG ZHANG
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  • For correspondence: x.zhang@baclesse.fr
EDWIGE DESLANDES
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MARIE VILLEDIEU
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LAURENT POULAIN
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MARILYNE DUVAL
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PASCAL GAUDUCHON
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LAURENT SCHWARTZ
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PHILIPPE ICARD
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Abstract

Background: 2-Deoxy-D-glucose (2-DG) is an analog of glucose that is preferentially captured by tumors and is accumulated in transformed cells, because the phosphorylated molecule (2-DG-6P) cannot be metabolized or diffused outside the cells. Targeted with a fluorine atom, 18F-DG is currently used to visualize malignant tumors (PET scan). Although cancer cells have been reported to be strongly dependent on glycolysis (Warburg effect), very few reports have studied the inhibitory effects of 2-DG on cancer. Materials and Methods: Our objective was to study, in a large panel of human malignant cells of various origins (ovarian, squamous, cerebral, hepatic, colonic and mesothelial), if the inhibitory activity of 2DG against tumor growth could be considered a general phenomenon and to determine its effect on the cell cycle. Results: Four types of response in the different cell lines were observed when cells were cultured in the presence of 2-DG (5 mM) continuous exposure: proliferation slow down; proliferation arrest without signs of apoptosis; strong cell cycle arrest accompanied by moderate apoptosis induction; massive apoptosis. Conclusion: 2-DG appears as an interesting new therapeutic agent against cancer in vitro, and should be tested in in vivo studies.

  • Energetic metabolism
  • glycolysis

Footnotes

    • Received March 28, 2006.
    • Accepted June 5, 2006.
    • Copyright© 2006 International Institute of Anticancer Research (Dr. John G. Delinassios), All rights reserved
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    Anticancer Research: 26 (5A)
    Anticancer Research
    Vol. 26, Issue 5A
    September-October 2006
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    Effect of 2-Deoxy-D-glucose on Various Malignant Cell Lines In Vitro
    XIAO DONG ZHANG, EDWIGE DESLANDES, MARIE VILLEDIEU, LAURENT POULAIN, MARILYNE DUVAL, PASCAL GAUDUCHON, LAURENT SCHWARTZ, PHILIPPE ICARD
    Anticancer Research Sep 2006, 26 (5A) 3561-3566;

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    Effect of 2-Deoxy-D-glucose on Various Malignant Cell Lines In Vitro
    XIAO DONG ZHANG, EDWIGE DESLANDES, MARIE VILLEDIEU, LAURENT POULAIN, MARILYNE DUVAL, PASCAL GAUDUCHON, LAURENT SCHWARTZ, PHILIPPE ICARD
    Anticancer Research Sep 2006, 26 (5A) 3561-3566;
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