Abstract
Background: Nucleophosmin-anaplastic lymphoma kinase expression is associated with a lymphoid malignancy, anaplastic large cell lymphoma, and is characterized by a t(2;5) chromosomal translocation. Materials and Methods: We describe a novel transgenic mouse line in which NPM-ALK expression is targeted to the T-cell lineage using the CD2 promoter. Results: Surprisingly, the mice develop B cell lymphomas in the majority of cases. Conclusion: These data stress the importance of choice of promoter to drive transgene expression in obtaining the desired phenotype.
Footnotes
- Received July 13, 2006.
- Accepted July 28, 2006.
- Copyright© 2006 International Institute of Anticancer Research (Dr. John G. Delinassios), All rights reserved
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