Serum Interleukin-6 Levels in Patients with Gastric MALT Lymphoma Compared to Gastric and Pancreatic Cancer

Abstract

Background: Interleukin-6 (IL-6) plays a major role in inflammatory processes and various malignancies. Serum IL-6 levels from patients with gastric MALT lymphoma, gastric cancer and pancreatic cancer was investigated. Patients and Methods: The serum Il-6 levels were obtained in a total of 86 patients. A two-tailed Mann-Whitney-test was performed to compare the results. A p-level <0.05 was deemed statistically significant. Results: In lymphoma patients, the mean IL-6 levels were 12.633 pg/ml (SD 10.465). The levels for gastric cancer were 6.324 pg/ml (SD 11.497) and 27.4 pg/ml (SD 86.272) for pancreatic cancer. A comparison between MALT lymphoma and gastric cancer revealed a significant difference (p=0.0030), while no difference was found between MALT lymphoma and pancreatic cancer. The Il-6 levels, however, were higher in pancreatic cancer than gastric cancer (p=0.0040). Conclusion: Our results might reflect a greater importance of IL-6 in the development and growth of MALT lymphoma and, possibly, pancreatic cancer than in gastric cancer.