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Research ArticleClinical Studies

Serum TRACP 5b and ICTP as Markers of Bone Metastases in Breast Cancer

J. KORPELA, S.L. TIITINEN, H. HIEKKANEN, J.M. HALLEEN, K.S. SELANDER, H.K. VÄÄNÄNEN, P. SUOMINEN, H. HELENIUS and E. SALMINEN
Anticancer Research July 2006, 26 (4B) 3127-3132;
J. KORPELA
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  • For correspondence: jaakor@utu.fi
S.L. TIITINEN
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H. HIEKKANEN
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J.M. HALLEEN
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K.S. SELANDER
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H.K. VÄÄNÄNEN
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P. SUOMINEN
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H. HELENIUS
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E. SALMINEN
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Abstract

Background: The purpose of this cross-sectional study was to evaluate the value of serum tartrate-resistant acid phosphatase 5b (TRACP 5b) and carboxyterminal telopeptide of type I collagen (ICTP) separately and in combination as markers of bone metastases compared to total alkaline phosphatase (tALP) in breast cancer. Materials and Methods: Two groups of patients were studied, one with verified bone metastases (N=46) and one without bone metastases (N=141). Bone marker levels were correlated with the presence or absence of bone metastases. Results: Serum TRACP 5b concentrations exhibited the largest area under the receiver-operating characteristics (ROC) curve (AUC=0.845), followed by ICTP (0.818) and tALP (0.814) when all patients were included in the analysis. With the combination of TRACP 5b and ICTP, the AUC increased to 0.881. In multivariate regression analysis, all three markers were significant predictors of bone metastases. Conclusion: Serum TRACP 5b, ICTP and tALP exhibited equal performances in the detection of bone metastases. The combination of TRACP with ICTP did not significantly improve the detection of bone metastases over tALP.

  • Breast cancer
  • bone metastasis markers
  • TRACP 5b
  • ICTP
  • tALP

Footnotes

  • Received March 20, 2006.
  • Accepted April 13, 2006.
  • Copyright© 2006 International Institute of Anticancer Research (Dr. John G. Delinassios), All rights reserved
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Anticancer Research: 26 (4B)
Anticancer Research
Vol. 26, Issue 4B
July-August 2006
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Serum TRACP 5b and ICTP as Markers of Bone Metastases in Breast Cancer
J. KORPELA, S.L. TIITINEN, H. HIEKKANEN, J.M. HALLEEN, K.S. SELANDER, H.K. VÄÄNÄNEN, P. SUOMINEN, H. HELENIUS, E. SALMINEN
Anticancer Research Jul 2006, 26 (4B) 3127-3132;

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Serum TRACP 5b and ICTP as Markers of Bone Metastases in Breast Cancer
J. KORPELA, S.L. TIITINEN, H. HIEKKANEN, J.M. HALLEEN, K.S. SELANDER, H.K. VÄÄNÄNEN, P. SUOMINEN, H. HELENIUS, E. SALMINEN
Anticancer Research Jul 2006, 26 (4B) 3127-3132;
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