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Research Article

Antiproliferative Activity of Vitamin D Compounds in Combination with Cytostatics

MARZENA PELCZYNSKA, MARTA SWITALSKA, MAGDALENA MACIEJEWSKA, IWONA JAROSZEWICZ, ANDRZEJ KUTNER and ADAM OPOLSKI
Anticancer Research July 2006, 26 (4A) 2701-2705;
MARZENA PELCZYNSKA
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  • For correspondence: mapelcz@iitd.pan.wroc.pl
MARTA SWITALSKA
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MAGDALENA MACIEJEWSKA
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IWONA JAROSZEWICZ
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ANDRZEJ KUTNER
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ADAM OPOLSKI
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Abstract

Calcitriol is a potent antiproliferative agent against various tumour cells in vitro. Here, the results of a study on vitamin D compounds (calcitriol's analogues PRI-1906 and PRI-2191) as potential agents in combined antitumour therapy in vitro are presented. Applying antiproliferative SRB and MTT assays, the growth inhibitory effects of the vitamin D compounds, applied alone or in combination with either cisplatin or doxorubicin, were measured. The following cancer cell lines were employed: A549 (human non-small cell lung carcinoma), B16 (murine melanoma), CCRF, HL-60 (human leukaemia), SW707 (human colon cancer), MCF-7, T47D (human breast cancer), WEHI-3 (mouse leukaemia) and normal cells: BALB 3T3 (normal murine fibroblast cell line). It was shown that the treatment of tumour cells, which are sensitive to vitamin D compounds, with the combination of vitamin D compounds and cytostatics decreased the inhibitory concentration 50% (IC50) values compared with the effects of the cytostatics applied alone.

  • Calcitriol
  • vitamin D analogues
  • combined treatment
  • cisplatin
  • doxorubicin
  • in vitro assay
  • cancer

Footnotes

  • Abbreviations: VDR, vitamin D receptor; PRI-1906, new analogue of vitamin D2; PRI-2191, new analogue of vitamin D3; IC50, inhibitory concentration 50%; SD, standard deviation.

  • Received March 10, 2006.
  • Accepted March 27, 2006.
  • Copyright© 2006 International Institute of Anticancer Research (Dr. John G. Delinassios), All rights reserved
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Anticancer Research: 26 (4A)
Anticancer Research
Vol. 26, Issue 4A
July-August 2006
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Antiproliferative Activity of Vitamin D Compounds in Combination with Cytostatics
MARZENA PELCZYNSKA, MARTA SWITALSKA, MAGDALENA MACIEJEWSKA, IWONA JAROSZEWICZ, ANDRZEJ KUTNER, ADAM OPOLSKI
Anticancer Research Jul 2006, 26 (4A) 2701-2705;

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Antiproliferative Activity of Vitamin D Compounds in Combination with Cytostatics
MARZENA PELCZYNSKA, MARTA SWITALSKA, MAGDALENA MACIEJEWSKA, IWONA JAROSZEWICZ, ANDRZEJ KUTNER, ADAM OPOLSKI
Anticancer Research Jul 2006, 26 (4A) 2701-2705;
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