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Research ArticleExperimental Studies

Anticancer Effect of Extracts from a North American Medicinal Plant - Wild Sarsaparilla

JENNIFER WANG, QIUZHU LI, GERALD IVANOCHKO and YAOGE HUANG
Anticancer Research May 2006, 26 (3A) 2157-2164;
JENNIFER WANG
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QIUZHU LI
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GERALD IVANOCHKO
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YAOGE HUANG
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  • For correspondence: yaogehuang@hotmail.com
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Abstract

The wild sarsaparilla (Aralia nudicaulis) plant is richly distributed in North America, mainly in Canada. In the present study, 24 extracts were obtained from the rhizome, stem, leaf and fruit of wild sarsaparilla. In the presence of RH (hexane fraction from the rhizome), the survival rate of WiDr (human colon cancer cell) was 3.5±2.7% (IC50=30.1±3.5 μg/ml) and that of Molt (human leukemia cell) was 2.4±2.8% (IC50=7.0±0.6 μg/ml). The survival rate of HELA (human cervix cancer cell) was only 1.8±0.9% in the presence of FH (hexane fraction from the fruit of wild sarsaparilla) (IC50=33.3±2.7 μg/ml). The cytotoxicities of RH and FH against normal human umbilical vein endothelial cells were significantly lower than against the tested human cancer cells. RH appeared to be the best extract against WiDr and Molt, whereas FH was the most effective against HELA. Because of the rich natural supply, simple extraction procedure and high yield, RH and FH of wild sarsaparilla have the potential to be developed into selective anticancer nutraceutical and/or pharmaceutical products with few side-effects and low cost.

  • Cytotoxicity
  • anticancer
  • wild sarsaparilla (Aralia nudicaulis)
  • North America
  • natural health product
  • medicinal plant

Footnotes

  • Received January 24, 2006.
  • Revision received April 14, 2006.
  • Accepted April 18, 2006.
  • Copyright© 2006 International Institute of Anticancer Research (Dr. John G. Delinassios), All rights reserved
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Anticancer Research: 26 (3A)
Anticancer Research
Vol. 26, Issue 3A
May-June 2006
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Anticancer Effect of Extracts from a North American Medicinal Plant - Wild Sarsaparilla
JENNIFER WANG, QIUZHU LI, GERALD IVANOCHKO, YAOGE HUANG
Anticancer Research May 2006, 26 (3A) 2157-2164;

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Anticancer Effect of Extracts from a North American Medicinal Plant - Wild Sarsaparilla
JENNIFER WANG, QIUZHU LI, GERALD IVANOCHKO, YAOGE HUANG
Anticancer Research May 2006, 26 (3A) 2157-2164;
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