Skip to main content

Main menu

  • Home
  • Current Issue
  • Archive
  • Info for
    • Authors
    • Subscribers
    • Advertisers
    • Editorial Board
  • Other Publications
    • In Vivo
    • Cancer Genomics & Proteomics
    • Cancer Diagnosis & Prognosis
  • More
    • IIAR
    • Conferences
    • 2008 Nobel Laureates
  • About Us
    • General Policy
    • Contact
  • Other Publications
    • Anticancer Research
    • In Vivo
    • Cancer Genomics & Proteomics

User menu

  • Register
  • Subscribe
  • My alerts
  • Log in
  • My Cart

Search

  • Advanced search
Anticancer Research
  • Other Publications
    • Anticancer Research
    • In Vivo
    • Cancer Genomics & Proteomics
  • Register
  • Subscribe
  • My alerts
  • Log in
  • My Cart
Anticancer Research

Advanced Search

  • Home
  • Current Issue
  • Archive
  • Info for
    • Authors
    • Subscribers
    • Advertisers
    • Editorial Board
  • Other Publications
    • In Vivo
    • Cancer Genomics & Proteomics
    • Cancer Diagnosis & Prognosis
  • More
    • IIAR
    • Conferences
    • 2008 Nobel Laureates
  • About Us
    • General Policy
    • Contact
  • Visit us on Facebook
  • Follow us on Linkedin
Research ArticleExperimental Studies

Changes in Cytokine Profile During Local IL-2 Therapy in Cancer Patients

RADOSVETA TOMOVA, JAVOR POMAKOV, JOHN J.L. JACOBS, DIMCHO ADJAROV, SVETLANA POPOVA, ISKRA ALTANKOVA, WILLEM DEN OTTER and ZACHARY KRASTEV
Anticancer Research May 2006, 26 (3A) 2037-2047;
RADOSVETA TOMOVA
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • For correspondence: raditomova@yahoo.com
JAVOR POMAKOV
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
JOHN J.L. JACOBS
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
DIMCHO ADJAROV
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
SVETLANA POPOVA
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
ISKRA ALTANKOVA
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
WILLEM DEN OTTER
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
ZACHARY KRASTEV
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • Article
  • Info & Metrics
  • PDF
Loading

Abstract

Background: Exogenous interleukin 2 (IL-2) can influence the complex cytokine network in vivo. This study investigated the cytokine profile of patients with different malignancies before and after local IL-2 administration. Patients and Methods: The human TH1 / TH2 cytometric bead array (CBA) kit was used to investigate IL-2, IFNγ, TNFα, IL-4, IL-5 and IL-10 in a control group and in 13 patients. Results: The baseline serum IL-4 levels in patients were lower than in healthy controls, while the baseline ascitic IL-10 levels in patients was higher than in serum. The IL-2 applications induced a strong serum increase in IL-2 and IL-5 and even more in ascites, while IL-10 increased weakly and mainly locally. One month after the start of therapy, the serum IFNγ had increased in patients, reaching the level of the control group. Conclusion: After local injection, IL-2 probably leaks into the blood circulation. The higher increases of IL-2, IL-5 and IL-10 in ascites compared to the serum suggests that the injected cytokines and their effects are mainly local. The minor increase of the immunosuppressive IL-10 could explain the therapeutic difference between local and systemic IL-2 therapy since IL-10 levels markedly increase after systemic IL-2 therapy. IL-5 was always increased after IL-2 therapy and, consequently, may be a downstream mediator of antitumour responses.

  • IL-2 therapy
  • cytokines
  • IL-5
  • IL-10

Footnotes

  • Received December 16, 2005.
  • Accepted February 8, 2006.
  • Copyright© 2006 International Institute of Anticancer Research (Dr. John G. Delinassios), All rights reserved
PreviousNext
Back to top

In this issue

Anticancer Research: 26 (3A)
Anticancer Research
Vol. 26, Issue 3A
May-June 2006
  • Table of Contents
  • Table of Contents (PDF)
  • Index by author
  • Front Matter (PDF)
Download PDF
Article Alerts
Sign In to Email Alerts with your Email Address
Email Article

Thank you for your interest in spreading the word on Anticancer Research.

NOTE: We only request your email address so that the person you are recommending the page to knows that you wanted them to see it, and that it is not junk mail. We do not capture any email address.

Enter multiple addresses on separate lines or separate them with commas.
Changes in Cytokine Profile During Local IL-2 Therapy in Cancer Patients
(Your Name) has sent you a message from Anticancer Research
(Your Name) thought you would like to see the Anticancer Research web site.
CAPTCHA
This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.
2 + 9 =
Solve this simple math problem and enter the result. E.g. for 1+3, enter 4.
Citation Tools
Changes in Cytokine Profile During Local IL-2 Therapy in Cancer Patients
RADOSVETA TOMOVA, JAVOR POMAKOV, JOHN J.L. JACOBS, DIMCHO ADJAROV, SVETLANA POPOVA, ISKRA ALTANKOVA, WILLEM DEN OTTER, ZACHARY KRASTEV
Anticancer Research May 2006, 26 (3A) 2037-2047;

Citation Manager Formats

  • BibTeX
  • Bookends
  • EasyBib
  • EndNote (tagged)
  • EndNote 8 (xml)
  • Medlars
  • Mendeley
  • Papers
  • RefWorks Tagged
  • Ref Manager
  • RIS
  • Zotero
Reprints and Permissions
Share
Changes in Cytokine Profile During Local IL-2 Therapy in Cancer Patients
RADOSVETA TOMOVA, JAVOR POMAKOV, JOHN J.L. JACOBS, DIMCHO ADJAROV, SVETLANA POPOVA, ISKRA ALTANKOVA, WILLEM DEN OTTER, ZACHARY KRASTEV
Anticancer Research May 2006, 26 (3A) 2037-2047;
del.icio.us logo Digg logo Reddit logo Twitter logo Facebook logo Google logo Mendeley logo
  • Tweet Widget
  • Facebook Like
  • Google Plus One

Jump to section

  • Article
  • Info & Metrics
  • PDF

Related Articles

  • No related articles found.
  • PubMed
  • Google Scholar

Cited By...

  • Treatment of Transmissible Venereal Tumors in Dogs with Intratumoral Interleukin-2 (IL-2). A Pilot Study
  • Role of Marker Lesion when Applying Intravesical Instillations of IL-2 for Non-muscle-invasive Bladder Cancer Comparison of the Therapeutic Effects in Two Pilot Studies
  • Low-dose IL-2 Therapy Reduces HCV RNA and HBV DNA: Case Report
  • Cytosine Deaminase-Uracil Phosphoribosyltransferase and Interleukin (IL)-12 and IL-18: A Multimodal Anticancer Interface Marked by Specific Modulation in Serum Cytokines
  • Google Scholar

More in this TOC Section

  • PTPN3 Could Βe a Therapeutic Target of Pancreatic Cancer
  • Murine Double Minute 2 Antagonist Nutlin-3 Enhanced Chemosensitivity in Esophageal Squamous Cell Carcinoma
  • Potent Imidazothiazole-based Inhibitor of BRAF V600E Overcomes Acquired Resistance via Inhibition of RAF Dimerization in PLX4032-resistant Melanoma
Show more Experimental Studies

Similar Articles

Anticancer Research

© 2022 Anticancer Research

Powered by HighWire