Table of Contents

Experimental Studies

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  A Direct Mechanistic Link between Growth Control and a Tumor Cell Immune Function: Increased Interleukin-8 Secretion Accounts for Elimination of Oct-1 Antisense Transformants from Scid Mice

  KIMBERLY M. PALUBIN, BONNIE L. GOODWIN, MELISSA I. NIESEN, ELIZABETH A. LE, AARON R. OSBORNE and GEORGE BLANCK

  Anticancer Research May 2006, 26 (3A) 1733-1738;
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  Gallium Maltolate is a Promising Chemotherapeutic Agent for the Treatment of Hepatocellular Carcinoma

  MEI-SZE CHUA, LAWRENCE R. BERNSTEIN, RUI LI and SAMUEL K.S. SO

  Anticancer Research May 2006, 26 (3A) 1739-1743;
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  Targeting a Methioninase-containing Fusion Protein to Breast Cancer Urokinase Receptors Inhibits Growth and Migration

  XIAO-PING ZANG, NAVEEN R. PALWAI, MEGAN R. LERNER, DANIEL J. BRACKETT, J. THOMAS PENTO and ROGER G. HARRISON

  Anticancer Research May 2006, 26 (3A) 1745-1751;
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  Tetrathiomolybdate Blocks bFGF- but not VEGF-induced Incipient Angiogenesis In Vitro

  FATEMA MAMOU, KERSTIN S. MAY, MATTHEW J. SCHIPPER, NAVKIRANJIT GILL, MUHAMMED S.T. KARIAPPER, BINDU M. NAIR, GEORGE BREWER, DANIEL NORMOLLE and MOHAMED K. KHAN

  Anticancer Research May 2006, 26 (3A) 1753-1758;
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  Antibody-dependent Cell Cytotoxicity to Breast Cancer Targets Despite Inhibitory KIR Signaling

  MARK N. STEIN, JAMES SHIN, OKSANA GUDZOWATY, ANDREW M. BERNSTEIN and JOHNSON M. LIU

  Anticancer Research May 2006, 26 (3A) 1759-1763;
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  Ex Vivo Assessment of Chemotherapy-induced Apoptosis and Associated Molecular Changes in Patient Tumor Samples

  FARZANEH PIRNIA, STEFFEN FRESE, BEAT GLOOR, MICHEL A. HOTZ, ALEXANDER LUETHI, MATHIAS GUGGER, DANIEL C. BETTICHER and MARKUS M. BORNER

  Anticancer Research May 2006, 26 (3A) 1765-1772;
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  Keratinocyte Growth Factor (KGF) Induces Tamoxifen (Tam) Resistance in Human Breast Cancer MCF-7 Cells

  HSIANG-LIN CHANG, YASURO SUGIMOTO, SULING LIU, WEIPING YE, LI-SHU WANG, YI-WEN HUANG and YOUNG C. LIN

  Anticancer Research May 2006, 26 (3A) 1773-1784;
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  Expression of the p53 Family in Lung Cancer

  HIDETAKA URAMOTO, KENJI SUGIO, TSUNEHIRO OYAMA, SHOJI NAKATA, KENJI ONO, TADAHIRO NOZOE and KOSEI YASUMOTO

  Anticancer Research May 2006, 26 (3A) 1785-1790;
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  Aberrant Methylation of the CHFR Gene in Digestive Tract Cancer

  YUKI MORIOKA, KENJI HIBI, MITSURU SAKAI, MASAHIKO KOIKE, MICHITAKA FUJIWARA, YASUHIRO KODERA, KATSUKI ITO and AKIMASA NAKAO

  Anticancer Research May 2006, 26 (3A) 1791-1795;
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  Intestinal Adenomas of Min-mice Lack Enterochromaffin Cells, and have Increased Lysozyme Production in Non-Paneth Cells

  TRINE HUSØY, HELLE K. KNUTSEN, ELSE MARIT LØBERG and JAN ALEXANDER

  Anticancer Research May 2006, 26 (3A) 1797-1802;
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  Prevalent Location of Flat Dysplastic Aberrant Crypt Foci near Lymphoid Follicles in the Colon of Azoxymethane-treated Rats

  JAN ERIK PAULSEN, INGER-LISE STEFFENSEN, HEGE BENEDIKTE ØLSTØRN and JAN ALEXANDER

  Anticancer Research May 2006, 26 (3A) 1803-1807;
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  Clinical Role of ABCF2 Expression in Breast Cancer

  YOSHINARI OGAWA, HIROSHI TSUDA, EISHU HAI, NOZOMI TSUJI, SHIGETO YAMAGATA, SHINYA TOKUNAGA, KAZUNORI NAKAZAWA, YUTAKA TAMAMORI, MASAO OGAWA, SADATOSHI SHIMIZU, TAKESHI INOUE and YUKIO NISHIGUCHI

  Anticancer Research May 2006, 26 (3A) 1809-1814;
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  Platinum (II) Complexes with Stereochemically-defined Thiepane Dioxide Diamine Ligands as Anticancer Drugs

  VANDA CERÈ, LORIS GROSSI, DANIELA MUNARI, SALVATORE POLLICINO, LAURA MARTELLI and MARIO MARTELLI

  Anticancer Research May 2006, 26 (3A) 1815-1819;
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  MIB-1 Labelling Indices According to Clinico-pathological Variables in Canine Mammary Tumours: A Multivariate Study

  AUGUSTO JOSÉ FERREIRA DE MATOS, CÉLIA CRISTINA CARREIRAS LOPES, AUGUSTO MANUEL RODRIGUES FAUSTINO, JÚLIO GIL VALE CARVALHEIRA, MARTA SUSANA AMARO DOS SANTOS, GERARD RÖELS RUTTEMAN and MARIA DE FÁTIMA RODRIGUES MOUTINHO GäRTNER

  Anticancer Research May 2006, 26 (3A) 1821-1826;
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  Effect of IgG Produced by Tumor-infiltrating B Lymphocytes on Lung Tumor Growth

  MAKIKO MIZUKAMI, TAKESHI HANAGIRI, YOSHIKI SHIGEMATSU, TETSURO BABA, TAKASHI FUKUYAMA, YOSHIKA NAGATA, TETSUYA SO, YOSHINOBU ICHIKI, MASAKAZU SUGAYA, MANABU YASUDA, TOMOKO SO, MITSUHIRO TAKENOYAMA, KENJI SUGIO and KOSEI YASUMOTO

  Anticancer Research May 2006, 26 (3A) 1827-1831;
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  Vascular Endothelial Growth Factor and Dendritic Cells in Human Squamous Cell Carcinoma of the Oral Cavity

  KENTARO KIKUCHI, KAORU KUSAMA, MAKOTO SANO, YOKO NAKANISHI, TOSHIYUKI ISHIGE, SUMIE OHNI, TOSHINORI OINUMA and NORIMICHI NEMOTO

  Anticancer Research May 2006, 26 (3A) 1833-1848;
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  Apoptosis-related Gene Expression in Benign Prostatic Hyperplasia and Prostate Carcinoma

  F. IACOPINO, C. ANGELUCCI, G. LAMA, G. ZELANO, G. LA TORRE, A. D'ADDESSI, C. GIOVANNINI, A. BERTACCINI, M. PAVONE MACALUSO, G. MARTORANA and G. SICA

  Anticancer Research May 2006, 26 (3A) 1849-1854;
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  Growth Inhibition and Apoptosis Induction by All-trans-conjugated Linolenic Acids on Human Colon Cancer Cells

  YUMIKO YASUI, MASASHI HOSOKAWA, HIROYUKI KOHNO, TAKUJI TANAKA and KAZUO MIYASHITA

  Anticancer Research May 2006, 26 (3A) 1855-1860;
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  Raloxifene Attenuation of 5-FU/Methotrexate Cytotoxicity in Human Breast Cancer Cells: The Importance of Sequence in Combination Chemotherapy

  ELIZABETH B. FRYAR, JHARNA R. DAS, JILLIAN H. DAVIS, JOSEPH A. DESOTO, IBRAHIM LANIYAN, WILLIAM M. SOUTHERLAND and DONNELL BOWEN

  Anticancer Research May 2006, 26 (3A) 1861-1867;
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  Proteasome Inhibition with Bortezomib Enhances Activity of Topoisomerase I-targeting Drugs by NF-κB-independent Mechanisms

  NAGIO TAKIGAWA, SUSAN A.J. VAZIRI, DALE R. GRABOWSKI, KENICHI CHIKAMORI, LISA R. RYBICKI, RONALD M. BUKOWSKI, MAHRUKH K. GANAPATHI, RAM GANAPATHI and TAREK MEKHAIL

  Anticancer Research May 2006, 26 (3A) 1869-1876;
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  Raloxifene Attenuation of Methotrexate Cytotoxicity in Human Bone Marrow by Sequence-dependent Administration of Raloxifene, 5-FU/Methotrexate

  JHARNA R. DAS, ELIZABETH B. FRYAR, NICOLAS N. EPIE, WILLIAM M. SOUTHERLAND and DONNELL BOWEN

  Anticancer Research May 2006, 26 (3A) 1877-1883;
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  VEGFR-3, VEGF-C and VEGF-D mRNA Quantification by RT-PCR in Different Human Cell Types

  DANY LECLERS, KARINE DURAND, JEANNE COOK-MOREAU, HÉLÈNE RABINOVITCH-CHABLE, FRANCK G. STURTZ and MICHEL RIGAUD

  Anticancer Research May 2006, 26 (3A) 1885-1891;
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  PARP Regulates TGF-β Receptor Type II Expression in Estrogen Receptor-positive Breast Cancer Cell Lines

  JULIE A. STERLING, LIANG WU and SUNANDITA S. BANERJI

  Anticancer Research May 2006, 26 (3A) 1893-1901;
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  Inhibition of Neuroblastoma Xenograft Growth by Hsp90 Inhibitors

  JUNGHEE KANG, ADEELA KAMAL, FRANCIS J. BURROWS, B. MARK EVERS and DAI H. CHUNG

  Anticancer Research May 2006, 26 (3A) 1903-1908;
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  DNA Damage Responses in Cell Cycle G₂ Phase and Mitosis - Tracking and Targeting

  ANNE HANSEN REE, TROND STOKKE, ÅSE BRATLAND, SEBASTIAN PATZKE, RAGNHILD V. NOME, SIGURD FOLKVORD, LEONARDO A. MEZA-ZEPEDA, KJERSTI FLATMARK, ØYSTEIN FODSTAD and YVONNE ANDERSSON

  Anticancer Research May 2006, 26 (3A) 1909-1916;
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  Apoptosis-inducing Activity of Trihaloacetylazulenes against Human Oral Tumor Cell Lines

  YOSHIAKI AKATSU, NOBUHARU OHSHIMA, YOSHIE YAMAGISHI, MASAYUKI NISHISHIRO, HIDETSUGU WAKABAYASHI, TERUO KURIHARA, HIROTAKA KIKUCHI, TADASHI KATAYAMA, NOBORU MOTOHASHI, YUKO SHOJI, HIDEKI NAKASHIMA and HIROSHI SAKAGAMI

  Anticancer Research May 2006, 26 (3A) 1917-1923;
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  Molecular Mechanisms of (-)-Gossypol-induced Apoptosis in Human Prostate Cancer Cells

  YI-WEN HUANG, LI-SHU WANG, HSIANG-LIN CHANG, WEIPING YE, MICHAEL K. DOWD, PETER J. WAN and YOUNG C. LIN

  Anticancer Research May 2006, 26 (3A) 1925-1933;
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  In Situ Androgen Production in Human Gastric Carcinoma - Androgen Synthesizing and Metabolizing Enzymes

  YASUHIRO NAKAMURA, NORIHIRO SHIMADA, TAKASHI SUZUKI, AKIRA IMATANI, HITOSHI SEKINE, SYUICHI OHARA, TOORU SHIMOSEGAWA and HIRONOBU SASANO

  Anticancer Research May 2006, 26 (3A) 1935-1939;
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  Overexpression of p68 mRNA in Head and Neck Squamous Cell Carcinoma Cells

  ULF HENNING BEIER, STEFFEN MAUNE, JENS E. MEYER and TIBOR GÖRÖGH

  Anticancer Research May 2006, 26 (3A) 1941-1946;
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  Alteration of Gene Expression in Melanoma Cells Following Combined Treatment with E2F-1 and Doxorubicin

  HONGYING HAO, YAN BIN DONG, MARIA T. BOWLING, H. SAM ZHOU and KELLY M. McMASTERS

  Anticancer Research May 2006, 26 (3A) 1947-1956;
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  Successful Gene Transfer into Dendritic Cells with Cationized Gelatin and Plasmid DNA Complexes Via a Phagocytosis-dependent Mechanism

  SATOSHI INADA, HITOSHI FUJIWARA, KIYOTO ATSUJI, KAZUHIRO TAKASHIMA, YASUNOBU ARAKI, TAKESHI KUBOTA, YASUHIKO TABATA and HISAKAZU YAMAGISHI

  Anticancer Research May 2006, 26 (3A) 1957-1963;
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  Involvement of Bax, Bcl-2, Ca²⁺ and Caspase-3 in Capsaicin-induced Apoptosis of Human Leukemia HL-60 Cells

  MEI-FEN TSOU, HSU-FENG LU, SSU-CHING CHEN, LII-TZU WU, YI-SHUAN CHEN, HSIU-MAAN KUO, SONG-SHEI LIN and JING-GUNG CHUNG

  Anticancer Research May 2006, 26 (3A) 1965-1971;
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  Antitumor Activity of TZT-1027 (Soblidotin)

  JUNICHI WATANABE, MEGUMI MINAMI and MOTOHIRO KOBAYASHI

  Anticancer Research May 2006, 26 (3A) 1973-1981;
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  Molecular Determinants of Differential Sensitivity to Docetaxel and Paclitaxel in Human Pediatric Cancer Models

  ELZBIETA IZBICKA, DAVID CAMPOS, JENNIFER MARTY, GILBERT CARRIZALES, GINA MANGOLD and ANTHONY TOLCHER

  Anticancer Research May 2006, 26 (3A) 1983-1988;
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  Differential Expression and Functional Characterization of System L Amino Acid Transporters in Human Normal Osteoblast Cells and Osteogenic Sarcoma Cells

  SU-GWAN KIM, HYUN-HO KIM, HAK-KYUN KIM, CHANG-HYUN KIM, HONG SUNG CHUN, YOSHIKATSU KANAI, HITOSHI ENDOU and DO KYUNG KIM

  Anticancer Research May 2006, 26 (3A) 1989-1996;
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  Cytotoxicity of Different Platinum (II) Analogues to Human Tumour Cell Lines In Vitro and Murine Tumour In Vivo Alone or Combined with Electroporation

  MAJA CEMAZAR, ZIVA PIPAN, SABINA GRABNER, NATASA BUKOVEC and GREGOR SERSA

  Anticancer Research May 2006, 26 (3A) 1997-2002;
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  COX-2 Inhibitors Celecoxib and Rofecoxib Prevent Oxidative DNA Fragmentation

  CHRISTOPH MATTHIAS, MARIE THERESE SCHUSTER, SABINA ZIEGER and ULRICH HARRÉUS

  Anticancer Research May 2006, 26 (3A) 2003-2007;
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  Effect of Structural Modifications of Anthracyclines on the Ability to Overcome Drug Resistance of Cancer Cells

  MALGORZATA WASOWSKA, JOANNA WIETRZYK, ADAM OPOLSKI, JANUSZ OSZCZAPOWICZ and IRENA OSZCZAPOWICZ

  Anticancer Research May 2006, 26 (3A) 2009-2012;
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  Apoptosis of Breast Cancer MCF-7 Cells In Vitro is Induced Specifically by Yeast and Not by Fungal Mycelia

  MAMDOOH GHONEUM and SASTRY GOLLAPUDI

  Anticancer Research May 2006, 26 (3A) 2013-2022;
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  p53 Mutants Suppress ZBP-89 Function

  MORIHIRO OKADA, ARTHUR TESSIER, LONGCHUAN BAI and JUANITA L. MERCHANT

  Anticancer Research May 2006, 26 (3A) 2023-2028;
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  TAOS1, a Novel Marker for Advanced Esophageal Squamous Cell Carcinoma

  YOSHINAO KOMATSU, KENJI HIBI, YASUHIRO KODERA, SEIJI AKIYAMA, KATSUKI ITO and AKIMASA NAKAO

  Anticancer Research May 2006, 26 (3A) 2029-2032;
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  Plasmid DNA-induced Cytokines Together with Cyclophosphamide Decrease Size and Number of Melanoma Lung Metastases

  TOMASZ CICHON, RYSZARD SMOLARCZYK, ALEKSANDER SOCHANIK and STANISLAW SZALA

  Anticancer Research May 2006, 26 (3A) 2033-2036;
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  Changes in Cytokine Profile During Local IL-2 Therapy in Cancer Patients

  RADOSVETA TOMOVA, JAVOR POMAKOV, JOHN J.L. JACOBS, DIMCHO ADJAROV, SVETLANA POPOVA, ISKRA ALTANKOVA, WILLEM DEN OTTER and ZACHARY KRASTEV

  Anticancer Research May 2006, 26 (3A) 2037-2047;
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  Reducing the Cost of Screening Novel Agents Using the Hollow Fibre Assay

  S.D. SHNYDER, P.A. COOPER, A.J. SCALLY and M.C. BIBBY

  Anticancer Research May 2006, 26 (3A) 2049-2052;
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  7β-Hydroxycholesterol Blocked at C-3-OH Inhibits Growth of Rat Glioblastoma In Vivo: Comparison between 7β-Hydroxycholesteryl-3β(ester)-oleate and 7β-Hydroxycholesteryl-3β-O(ether)-oleyl

  CLOVIS RAKOTOARIVELO, MONIKA ADAMCZYK, MICHEL DESGEORGES, KEITH LANGLEY, JEAN-GEORGES LORENTZ, ANDRÉ MANN, DAMIEN RICARD, ELISABETH SCHERRER, ALAIN PRIVAT and MARCEL MERSEL

  Anticancer Research May 2006, 26 (3A) 2053-2062;
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  Expression of Four Histone Lysine-methyltransferases in Parotid Gland Tumors

  FRANCESCO ANIELLO, GIUSEPPE COLELLA, GIANLUCA MUSCARIELLO, ANTONIO LANZA, DIANA FERRARA, MARGHERITA BRANNO and SERGIO MINUCCI

  Anticancer Research May 2006, 26 (3A) 2063-2067;
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  Laser Microdissection and Microsatellite Analysis of Colorectal Adenocarcinomas

  LARS HENRIK JENSEN, DORTHE G. CRUGER, JAN LINDEBJERG, LENE BYRIEL, GERT BRUUN-PETERSEN and ANDERS JAKOBSEN

  Anticancer Research May 2006, 26 (3A) 2069-2074;
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  Pitfalls in Detection of Contaminating Neuroblastoma Cells by Tyrosine Hydroxylase RT-PCR Due to Catecholamine-producing Hematopoietic Cells

  ZYRAFETE KUÇI, GABRIELE SEITZ, SELIM KUÇI, HERMANN KREYENBERG, MICHAEL SCHUMM, PETER LANG, DIETRICH NIETHAMMER, RUPERT HANDGRETINGER and GERNOT BRUCHELT

  Anticancer Research May 2006, 26 (3A) 2075-2080;
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  Resveratrol Oligomers are Potent MRP1 Transport Inhibitors

  MALGORZATA BOBROWSKA-HÄGERSTRAND, MAGDALENA LILLÅS, LUCYNA MRÓWCZYÑSKA, ANNA WRÓBEL, YOSHIAKI SHIRATAKI, NOBORU MOTOHASHI and HENRY HÄGERSTRAND

  Anticancer Research May 2006, 26 (3A) 2081-2084;
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  In Vitro Combined Modality Treatment of Prostate Carcinoma Cells with 17-(allylamino)-17-demethoxygeldanamycin and Ionizing Radiation

  HANS-JOACHIM OCHEL and GÜNTHER GADEMANN

  Anticancer Research May 2006, 26 (3A) 2085-2091;
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  Cell Cycle Arrest and Apoptosis Induced by Oxaliplatin (L-OHP) on Four Human Cancer Cell Lines

  SARA WILLIAM-FALTAOS, DANY ROUILLARD, PHILIPPE LECHAT and GÉRARD BASTIAN

  Anticancer Research May 2006, 26 (3A) 2093-2099;
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  Altered Expression of DNA Double-strand Repair Genes Ku70 and Ku80 in Carcinomas of the Oral Cavity

  MONIKA KORABIOWSKA, JANN VOLTMANN, JOHANNES F. HÖNIG, PAWEL BORTKIEWICZ, FRANK KÖNIG, CARLOS CORDON-CARDO, FREDERIKE JENCKEL, PETRA AMBROSCH and GÖSTA FISCHER

  Anticancer Research May 2006, 26 (3A) 2101-2105;
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  Analysis of DNA Mismatch Repair Gene Expression and Mutations in Thyroid Tumours

  ILKA RUSCHENBURG, BEATE VOLLHEIM, JERZY STACHURA, CARLOS CORDON-CARDO and MONIKA KORABIOWSKA

  Anticancer Research May 2006, 26 (3A) 2107-2112;
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  Effect of Rosiglitazone on N-nitroso-N-methylurea-induced Mammary Tumors in Rat

  MARIEL NÚÑEZ, GABRIELA MARTÍN, CLAUDIA COCCA, NORA MOHAMAD, ALICIA GUTIÉRREZ, GRACIELA CRICCO, VANINA MEDINA, ELENA RIVERA, MÁXIMO CROCI, ERNESTO CRESCENTI and ROSA BERGOC

  Anticancer Research May 2006, 26 (3A) 2113-2122;
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  Notch3 Intracellular Domain Accumulates in HepG2 Cell Line

  CATIA GIOVANNINI, MICHELA LACCHINI, LAURA GRAMANTIERI, PASQUALE CHIECO and LUIGI BOLONDI

  Anticancer Research May 2006, 26 (3A) 2123-2127;
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  Indirubin-3′-monoxime, a CDK Inhibitor Induces Growth Inhibition and Apoptosis-independent Up-regulation of Survivin in Transitional Cell Cancer

  FRANK G.E. PERABO, CHRISTIAN FRÖSSLER, GREGOR LANDWEHRS, DORIS H. SCHMIDT, ALEXANDER VON RÜCKER, ANDREAS WIRGER and STEFAN C. MÜLLER

  Anticancer Research May 2006, 26 (3A) 2129-2135;
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  Identification of Differentially Expressed mRNA Transcripts in Drug-resistant Versus Parental Human Melanoma Cell Lines

  NIKOLA TANIC, GORDANA BRKIC, BOGOMIR DIMITRIJEVIC, NASTA DEDOVIC-TANIC, NIR GEFEN, DANIEL BENHARROCH and JACOB GOPAS

  Anticancer Research May 2006, 26 (3A) 2137-2142;
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  Down-regulation of Gadd45 Expression is associated with Tumor Differentiation in Non-small Cell Lung Cancer

  HIROSHI HIGASHI, DANIEL VALLBÖHMER, UTE WARNECKE-EBERZ, SHUICHI HOKITA, HUAN XI, JAN BRABENDER, RALF METZGER, STEPHAN E. BALDUS, SHOJI NATSUGOE, TAKASHI AIKOU, ARNULF H. HÖLSCHER and PAUL M. SCHNEIDER

  Anticancer Research May 2006, 26 (3A) 2143-2147;
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  GL331, a Topoisomerase II Inhibitor, Induces Radiosensitization of Human Glioma Cells

  YUN CHEN, TZU-YU LIN, JIN-CHERNG CHEN, HUNG-ZEN YANG and SHENG-HONG TSENG

  Anticancer Research May 2006, 26 (3A) 2149-2156;
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  Anticancer Effect of Extracts from a North American Medicinal Plant - Wild Sarsaparilla

  JENNIFER WANG, QIUZHU LI, GERALD IVANOCHKO and YAOGE HUANG

  Anticancer Research May 2006, 26 (3A) 2157-2164;
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  Comparative Effects of Hypoxia on Normal and Immortalized Human Diploid Fibroblasts

  EFTHYMIOS POULIOS, IOANNIS P. TROUGAKOS and EFSTATHIOS S. GONOS

  Anticancer Research May 2006, 26 (3A) 2165-2168;
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  Combination Treatment of Imatinib-sensitive and -resistant BCR-ABL-positive CML Cells with Imatinib and Farnesyltransferase Inhibitors

  ALEKSANDAR RADUJKOVIC, JULIAN TOPALY, STEFAN FRUEHAUF and W. JENS ZELLER

  Anticancer Research May 2006, 26 (3A) 2169-2177;
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  The Effect of the Substitution Level of Some Dextran-methotrexate Conjugates on their Antitumor Activity in Experimental Cancer Models

  DMITRY NEVOZHAY, RENATA BUDZYNSKA, MONIKA JAGIELLO, URSZULA KANSKA, MOHAMED SALAH OMAR, ADAM OPOLSKI, JOANNA WIETRZYK and JANUSZ BORATYNSKI

  Anticancer Research May 2006, 26 (3A) 2179-2186;