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Research ArticleClinical Studies

Potential Predictors of Long-term Survival after Surgery for Patients with Stage IV Colorectal Cancer

TSUKASA HOTTA, KATSUNARI TAKIFUJI, KAZUO ARII, SHOZO YOKOYAMA, KENJI MATSUDA, TAKASHI HIGASHIGUCHI, TOSHIJI TOMINAGA, YOSHIMASA OKU and HIROKI YAMAUE
Anticancer Research March 2006, 26 (2B) 1377-1383;
TSUKASA HOTTA
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KATSUNARI TAKIFUJI
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KAZUO ARII
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SHOZO YOKOYAMA
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KENJI MATSUDA
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TAKASHI HIGASHIGUCHI
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TOSHIJI TOMINAGA
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YOSHIMASA OKU
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HIROKI YAMAUE
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  • For correspondence: yamaue-h@wakayama-med.ac.jp
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Abstract

Background: The prognosis of patients with colorectal cancer is considered to be affected by several factors. Recently, chemotherapy for this disease has been demonstrated to be effective for long-term survival. In this study, the potential predictors, including chemotherapy regimens for survival after surgery, in patients with stage IV colorectal cancer are presented. Patients and Methods: Univariate and multivariate analyses of potential predictors of survival after surgery were carried out for 56 patients with stage IV colorectal cancer who had undergone surgery, including 22 with rectal and 34 with colon cancer. Results: The survival in patients who had had a primary liver resection was longer than that in patients who had not (p=0.007). There was a significant difference among chemotherapy regimens (p=0.021). The survival in patients who were administered l-leucovorin/5-fluorouracil (l-LV/5FU) was longer than that in patients who received uracil-tegafur (UFT) and cisplatin (CDDP)/5FU (p=0.024, p=0.004, respectively). In multivariate analyses, there were 5 favorable factors that influenced overall survival after surgery: lymph node metastasis (p=0.029), no bone metastasis (p=0.012), no peritoneal invasion (p=0.018), no primary liver resection (p=0.004) and the chemotherapy regimen (p=0.008). Furthermore, the survival in patients with a continued l-LV/5FU plus modified IFL regimen (additional irinotecan) was longer than for those patients who received other regimens, in both univariate and multivariate analyses. Conclusion: Five factors, namely lymph node metastasis, bone metastasis, peritoneal invasion, primary liver resection and chemotherapy, are potential predictors of survival after surgery for patients with stage IV colorectal cancer.

  • Colorectal cancer stage IV
  • l-LV/5FU
  • CPT-11

Footnotes

  • Received November 28, 2005.
  • Revision received February 2, 2006.
  • Accepted February 9, 2006.
  • Copyright© 2006 International Institute of Anticancer Research (Dr. John G. Delinassios), All rights reserved
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Anticancer Research: 26 (2B)
Anticancer Research
Vol. 26, Issue 2B
March-April 2006
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Potential Predictors of Long-term Survival after Surgery for Patients with Stage IV Colorectal Cancer
TSUKASA HOTTA, KATSUNARI TAKIFUJI, KAZUO ARII, SHOZO YOKOYAMA, KENJI MATSUDA, TAKASHI HIGASHIGUCHI, TOSHIJI TOMINAGA, YOSHIMASA OKU, HIROKI YAMAUE
Anticancer Research Mar 2006, 26 (2B) 1377-1383;

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Potential Predictors of Long-term Survival after Surgery for Patients with Stage IV Colorectal Cancer
TSUKASA HOTTA, KATSUNARI TAKIFUJI, KAZUO ARII, SHOZO YOKOYAMA, KENJI MATSUDA, TAKASHI HIGASHIGUCHI, TOSHIJI TOMINAGA, YOSHIMASA OKU, HIROKI YAMAUE
Anticancer Research Mar 2006, 26 (2B) 1377-1383;
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